Skip to main content
Fig. 2 | Virology Journal

Fig. 2

From: Eastern equine encephalitis virus in mice II: pathogenesis is dependent on route of exposure

Fig. 2

Immunohistochemical and histologic findings in mice after AE infection with EEEV strain FL93-939. Mice were infected with approximately 100LD50 and were euthanized at specified time points (n = 5, except 4dpi n = 10). Viral antigen was first detected in the olfactory nasal epithelium, lamina propria, and olfactory nerve (a magnification X200), as well as the olfactory bulb at 1 dpi (b magnification X200). Multifocally, viral antigen was present in the nasal cavity (c magnification X20), the olfactory nerve (c; inset, magnification X400), and cerebrum, especially the piriform cortex, by 2 dpi (d magnification X20). Viral antigen was present throughout the brain by 3 dpi (e magnification X20) and there was meningoencephalitis in the cerebrum (f magnification X200) and multifocal neuronal cell death (hypereosinophilic, shrunken neurons with pyknosis or karyorrhexis; inset, arrow)

Back to article page