Skip to main content
Fig. 5 | Virology Journal

Fig. 5

From: Up-regulation of A20/ABIN1 contributes to inefficient M1 macrophage polarization during Hepatitis C virus infection

Fig. 5

A20 and TfR1 affect macrophage phagocytosis activity differently. a NS3/4A stimulated macrophages endocytosed fewer HCVcc particles. b A20 suppression by RNA interference rescues phagocytosis activity. In contrast, TfR1 over-expression did not rescue phagocytosis. c Viral titers in culture medium from HCV antigens stimulation were significantly higher than normal controls (p < 0.001). d TfR1 over-expression, but not A20 knockdown, reduces viral load extracellularly. e A20 knockdown cannot rescue TfR1 expression at the transcription level

Back to article page