Virus
|
Octapeptide motif and mutation a
|
Plaque size b (Fig. 3)
|
NS1-2A cleavage (from Table 1)
|
---|
rMVEV
|
L-V-K-S-R-V-Q-A ↓
|
4 mm
|
88 %
|
rP3-Gly
|
L-V-K-S-R-G-Q-A ↓
|
4 mm
|
83 %
|
rP8-Ala
|
A-V-K-S-R-V-Q-A ↓
|
4 mm
|
80 %
|
-
aMutations introduced into the octapeptide are in bold and underlined, and arrow denotes the NS1-2A cleavage site
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bPlaque size on Vero cell monolayers stained with neutral red at 4 days pi and observed 16 h later