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Table 1 Amino acid substitutions in NS5A region of treatment-naïve patients infected with HCV genotypes 1a (n = 7) and 1b (n = 105)

From: Prevalence of hepatitis C virus (HCV) variants resistant to NS5A inhibitors in naïve patients infected with HCV genotype 1 in Tunisia

NS5A residues

Resistance mutations

Prevalence of observed resistance mutations (%)

DAAs

Genotypes

Genotypes

Genotypes

 

1a

1b

1a

1b

1a

1b

 
 

L23

 

F

  

Daclatasvir

M28

L28

T/V

M/V

V (1/7; 14.2 %)

 

Daclatasvir Ombitasvir

Q30

R30

H/E/R/K

Q

 

Q (6/105; 5.7 %)

Daclatasvir Ombitasvir

L31

L31

M/V

F/M/V

 

M (3/105; 2.8 %)

Daclatasvir Ledipasvir Ombitasvir

P32

P32

L

L

  

Daclatasvir

 

P58

 

S

 

S (4/105; 3.8 %)

Daclatasvir

Y93

Y93

C/H/N

C/H/N

 

H (6/105; 5.7 %)

Daclatasvir Ledipasvir Ombitasvir

  1. Data interpreted according to Krishnan et al. [19] Paolucci et al. [24] and Fridell et al. [27]
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Virology Journal

ISSN: 1743-422X