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Table 1 Main characteristics of included trials

From: Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis

Study

NCA

NCO

Mutation site

Detection method

Matching factors

     

Age

Sex

Genotype

HBV DNA

Aiming Zhang, 2013

29

52

T1753V, A1762T, G1764A, A1762T/G1764A, A1846T, G1896A, G1899A

NP, AS

+

+

+

+

Aiming Zhang2, 2013

58

51

T1753V, A1762T, G1764A, A1762T/G1764A, A1846T, G1896A, G1899A

NP, AS

+

+

+

+

Lei Xiao, 2013

77

136

T1753V, A1762T/G1764A, C1766T, T1768A, A1846T, G1862T, G1896A, G1899A

NP, AS

+

+

-

-

Xiaodong Li, 2013

146

239

T1753V, A1762T/G1764A, C1766T, T1768A, A1846T, G1896A, G1899A

NP, AS

+

+

-

-

X Ren, 2010 (40)

75

328

T1753V, A1762T, G1764A, C1766T, T1768A, G1896A, G1899A

NP, AS

+

+

+

+

Zhihui Xu, 2010

298

495

T1753V, A1762T, G1764A, C1766T, T1768A, G1862T, G1896A, G1899A

NP, AS

+

+

+

-

Ling Yang, 2010

39

44

A1762T/G1764A, G1862T, G1896A, G1899A

SNP, AS

-

+

+

-

Zhengang Zhao, 2010

20

19

T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, A1846T, G1862T, G1896A, G1899A, A1762T/G1764A/G1896A

NP, DS

-

+

+

-

Xiaoyan Ma, 2012

44

28

T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, A1846T, G1896A, G1899A, A1762T/G1764A/G1896A

NP, S

-

+

+

-

Zhiwei Li, 2002

13

10

A1846T, G1862T, G1896A

RP, SA

ND

ND

ND

-

Shoubing Tang, 2005

30

30

A1762T/G1764A, G1896A

RP, CS

+

+

ND

-

Yintang Jia, 2009

8

78

T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, A1846T, G1896A, G1899A

NP, DS

ND

ND

ND

-

Ling Jiang, 2013

146

239

A1762T/G1764A, G1896A

QPMK, DS

+

+

ND

-

Wenjun Du, 2005

9

75

A1762T, G1764A, G1896A

RP, GC, S

ND

ND

ND

-

Xiumei Zhou, 2009

80

80

A1762T/G1764A, G1896A, G1899A

RP, GC

+

+

ND

-

Mingxian Zhou, 2004

22

56

A1762T, G1896A

UK

ND

ND

+

-

Xiaoqiang Ren, 2009

348

610

T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, G1862T, G1896A, G1899A, A1762T/G1764A/G1896A

NP, AS

+

+

+

-

Lei Jiang, 2010

26

78

G1896A

NP, RFLP

ND

ND

ND

-

Jinqiang Li, 2006

30

20

A1762T/G1764A, G1896A

RP, MS

+

+

ND

-

Chengyong Liu, 2007

34

186

A1762T/G1764A, G1896A, A1762T/G1764A/G1896A

RP, MGS

ND

ND

ND

-

Xinyu Liu, 2005

14

75

A1762T, G1764A, A1762T/G1764A, G1896A, A1762T/G1764A/G1896A

LAS

ND

ND

ND

-

Shuren Liang, 2003

23

68

G1896A

RP, OAS

ND

+

ND

-

Zhidong Zang, 2007

17

81

A1762T/G1764A

RP, LAS

ND

ND

ND

-

Tao Yan, 2010

49

45

T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, A1846T, G1896A, G1899A, A1762T/G1764A/G1896A

NP, AS

-

+

+

-

Wei Guo, 2006

38

40

T1753V, A1762T, G1764A, A1762T/G1764A, C1766T, T1768A, G1862T, G1896A, G1899A, A1762T/G1764A/G1896A

RP, CS

+

+

ND

-

Yanhong Yu, 2008

25

98

A1762T/G1764A

RP, GC

ND

ND

ND

-

Guanghui Wu, 2008

30

30

A1762T/G1764A, G1896A

RP, RFLP

ND

+

+

-

Hangdi Xu, 2013

12

12

A1762T, G1764A, A1846T, G1896A

RP, IS

+

+

+

+

Fan Li, 2008 (31)

87

196

T1753V, A1762T, G1764A, G1862T, G1896A, G1899A

NP, AS

ND

+

ND

-

Lu Xu, 2012

64

69

T1753V, A1762T, G1764A, A1762T/G1764A, T1768A, G1862T, G1896A, G1899A, A1762T/G1764A/G1896A

RP, AS

+

-

ND

-

Hangdi Xu2, 2013

104

254

A1846T, G1896A

SNP, AS

ND

-

-

-

  1. NCA number of ACLF patients, NCO number of CHB patients, S sequencing, Apparatus unknown, NP nested PCR, SNP semi-nested PCR, RP routine PCR, AS ABI3730XL PRISM sequencing, SA Sequence Analysis, CS CEQ2000XL sequencing, DS direct sequencing, QPMK Quickchange point mutation kit, GC gene chip hybrid, UK unknown, RFLP restriction fragment length polymorphism, MS MegaBACE DNA sequencing, MGS Mgeabace-500 sequencing, LAS LicorIR2 Automatic DNA sequencing, OAS OpenGene Automated DNA Sequencing, IS Illumina sequencing, ND not determined, + = matched; - = unmatched; ABI PRISM 3730xl DNA Analyzer
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