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Table 1 Comparison of clinical manifestations between uncomplicated cases and severe cases

From: Enterovirus 71 infection in children with hand, foot, and mouth disease in Shanghai, China: epidemiology, clinical feature and diagnosis

  All cases Uncomplicated Severe Χ 2 P value*
(396) (73.74 %, 292) (26.26 %,104)
Male to female ratio 1.75 (252/144) 1.92 (192/100) 1.36 (60/44) 2.153 0.155
Fever > 3 days 16.41 % (65) 11.64 % (34) 29.81 % (31) 18.441 <0.0001
Oral rash 88.38 % (350) 89.38 %(261) 85.58 % (89) 1.082 0.291
Vomiting 45.45 % (180) 38.70 % (113) 64.42 % (67) 20.468 <0.0001
Headache 2.53 % (10) 2.05 % (6) 3.85 % (4) 1.000 0.298
Startle 57.32 % (227) 46.92 % (137) 86.54 % (90) 49.209 <0.0001
Convulsion 1.26 % (5) 0.68 % (2) 2.88 %(3) 2.976 0.116
Myoclonus 35.10 % (139) 21.92 % (64) 72.12 % (75) 84.826 <0.0001
EV71-RNA positive in stool 242 (61.11 %) 143 (48.97 %) 99 (95.19 %) 68.933 <0.0001
  1. *Chi-squared test was used to evaluate the significant variation of clinical manifestations between uncomplicated cases and severe cases. The p value less than 0.05 was considered to be significant and marked in bold