Enterovirus 71 infection in children with hand, foot, and mouth disease in Shanghai, China: epidemiology, clinical feature and diagnosis

Table 1 Comparison of clinical manifestations between uncomplicated cases and severe cases

	All cases	Uncomplicated	Severe	Χ ²	P value*
	(396)	(73.74 %, 292)	(26.26 %,104)	Χ ²	P value*
Male to female ratio	1.75 (252/144)	1.92 (192/100)	1.36 (60/44)	2.153	0.155
Fever > 3 days	16.41 % (65)	11.64 % (34)	29.81 % (31)	18.441	<0.0001
Oral rash	88.38 % (350)	89.38 %(261)	85.58 % (89)	1.082	0.291
Vomiting	45.45 % (180)	38.70 % (113)	64.42 % (67)	20.468	<0.0001
Headache	2.53 % (10)	2.05 % (6)	3.85 % (4)	1.000	0.298
Startle	57.32 % (227)	46.92 % (137)	86.54 % (90)	49.209	<0.0001
Convulsion	1.26 % (5)	0.68 % (2)	2.88 %(3)	2.976	0.116
Myoclonus	35.10 % (139)	21.92 % (64)	72.12 % (75)	84.826	<0.0001
EV71-RNA positive in stool	242 (61.11 %)	143 (48.97 %)	99 (95.19 %)	68.933	<0.0001

*Chi-squared test was used to evaluate the significant variation of clinical manifestations between uncomplicated cases and severe cases. The p value less than 0.05 was considered to be significant and marked in bold

ISSN: 1743-422X