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Figure 1 | Virology Journal

Figure 1

From: Residues 41V and/or 210D in the NP protein enhance polymerase activities and potential replication of novel influenza (H7N9) viruses at low temperature

Figure 1

Normalized polymerase activities of recombinant polymerase complexes between A/Quail/Hongkong/G1/1997 (H9N2) and A/Anhui/1/2013 (H7N9) (A & B), or different NPs in the backbone of A/Anhui/1/2013 (H7N9) PB2/PB1/PA plasmids (C & D). RNP activities were measured in triplicate based on a Gluc reporter system and normalized to AH1 RNP activity at 33°C (A, C) and 37°C (B, D). Abbreviations in A & B: G, A/Quail/Hongkong/G1/1997; A, A/Anhui/1/2013; Abbreviations in C & D: AH, A/Anhui/1/2013 (H7N9, AH1); G1, A/Quail/Hongkong/G1/1997 (H9N2, G1); QH, A/bar-headed goose/Qinghai/1/2005 (H5N1); GZ, A/Guangzhou/333/1999 (H9N2); CA04, A/California/04/2009 (2009pdmH1N1); and PR8, A/Puerto Rico/8/1934 (H1N1). Results are representative of three independent experiments.

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Virology Journal

ISSN: 1743-422X