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Table 6 Inhibition by Difluoro sialic acid inhibitors of A/Fukui/45/2004 agglutination of chicken RBCs and enzyme activity

From: The neuraminidases of MDCK grown human influenza A(H3N2) viruses isolated since 1994 can demonstrate receptor binding

Assay

DFSA nM c

FaxAm DFSA c nM

FeqAm DFSA c nM

FaxGu DFSA c nM

FeqGu DFSA c nM

aNAI-HI CRBC

100

100

10

100

100

TRBC

100

100

10

100

100

bEnzyme IC50

1380

4710

71

2006

25

  1. aNAI−HI assays were performed in duplicate with 4 HAUs of virus, 0.5% RBCs and log10 dilutions of NAIs.
  2. bIC50s from Kim et al. [30].
  3. cDFSA = Difluoro sialic acid; FaxAm = 3 F axial 4-amino; FeqAm = 3 F equatorial 4-amino; FaxGu = 3 F axial 4-guanidino, FeqGu = 3 F equatorial 4-guanidino.
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Virology Journal

ISSN: 1743-422X