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Table 4 HA and NA changes between egg and MDCK cultured pairs of influenza A H3N2 viruses

From: The neuraminidases of MDCK grown human influenza A(H3N2) viruses isolated since 1994 can demonstrate receptor binding

Influenza A H3N2

Pass

NAI-HI b

HA (H3) c

NA (N2)

CRBC

TRBC

131

138 d

158

167

186 e

190 d

193 e

194 d

229 e

246

148

221

312

399

Consensus a

   

A/T

A

K/E

T

S/G

D

S

L

R

N

T

K/E

I

D/E

A/Auckland/19/1996

Egg

-

       

R

       
 

MDCK

+

-

              

A/Auckland/5/1996

Egg

-

        

I

      
 

MDCK

+

-

          

I

   

A/Victoria/3/1999

Egg

-

        

I

I

     
 

MDCK

+

+/−

              

A/Perth/201/2001

Egg

-

   

N

    

I

I

     
 

MDCK

+

-

D

  

A

          

A/Christchurch/28/2003

Egg

-

  

S

  

D

V

        
 

MDCK

+

+

              

A/Brisbane/3/2005

Egg

-

     

V

    

K

    
 

MDCK

+

+

             

G

A/Brisbane/10/2007

Egg

-

        

P

   

K

  
 

MDCK

+

+

            

T

 
  1. aConsensus sequence based on alignment of HAs and NAs in this study.
  2. bSee Tables 2 and 3. As no egg grown viruses were inhibited with CRBC they were not tested with TRBC.
  3. cH3 numbering [26].
  4. dH3 receptor binding site amino acids [26].
  5. eEgg adaptation amino acids of H3N2 viruses [24].
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