The neuraminidases of MDCK grown human influenza A(H3N2) viruses isolated since 1994 can demonstrate receptor binding

Table 2 Haemagglutination titres of MDCK cultured H3N2 viruses in presence and absence of 1 μM oseltamivir

Virus	CRBC	CRBC + Osel ^a	Elution ^b	TRBC	TRBC+ Osel ^a	Elution ^b
A/Victoria/1/93	32-64	32-64	slow	64	64	slow
A/Victoria/4/94	2-4	<2	fast	8	8	med
A/Auckland/5/96	16	<2	fast	64	32	slow
A/Victoria/54/ 96	32	<2	slow	32	<2	slow
A/Auckland/19/96	16	<2	fast	32	16-32	slow
A/Victoria/6/97	8	<2	med	32	16	slow
A/Victoria/314/98	8	<2	fast	16	<2	med
A/Victoria/3/99	8	<2	slow	32	8	slow
A/Victoria/514/00	4-8	<2	slow	16	<2	slow
A/Perth/201/01	2	<2	med	16-32	16	slow
A/Perth/200/02	4	<2	fast	16	<2	slow
A/Christchurch/28/03	8	<2	med	16	<2	slow
A/Wellington/1/04	8	<2	fast	16	<2	med
A/Fukui/45/04	8	<2	med	16	<2	slow
A/Brisbane/3/05	2-4	<2	med	8	<2	slow
A/Victoria/503/06	4-8	<2	slow	4-8	<2	slow
A/Brisbane/10/07	4	<2	med	8-16	<2	slow
A/Brisbane/2/08	8-16	<2	slow	8-16	<2	slow

^aViruses were preincubated with oseltamivir at 4°C for 1 hour prior to the addition of 1% RBCs.
^bRate of elution of virus in the absence of inhibitor from RBC at 37°C, fast < 60 min, medium 1–3 hours, slow >3 hours.

ISSN: 1743-422X