Strain or isolates § | Characteristics (PI/NRTI/NNRTI-drug resistance-related mutation sites) | Subtype | Antiretroviral drugs | |||||
---|---|---|---|---|---|---|---|---|
Sample date | (PR/RT) | APV | IDV | DRV | EFV | ETR | ||
HIV-1 pNL4-3 | Wild type (None/None/None) | B/B | Genotypea (Mutation Score) | S (0) | S (0) | S (0) | S (0) | S (0) |
Phenotypeb (IC50, FC*) | 7.17 nM, 1 | 13.5 nM, 1 | 6.80E–01 nM, 1 | 4.40E–02 nM, 1 | 1.34E–02 nM, 1 | |||
KRB8067 | Treatment-experienced patient infected with HIV. Treatment with AZT, 3TC, and IDV from Jul. 2003 to Apr. 2006 | B/B | Genotype (Mutation Score) | R (60) | R (80) | S (0) | S (0) | S (0) |
(M46I,I54V,V82A,L10F/M184V/None) Apr. 24, 2006 | Phenotype (IC50, FC) | 3.52 nM, 0.5 | 34.4 nM, 2.6 | 8.58E–02 nM, 0.1 | 5.00E–02 nM, 1.1 | 7.99E–02 nM, 6.0 | ||
KRC2065 | Treatment-experienced patient infected with HIV. Treatment with AZT, 3TC, and IDV from May 2002 to Oct. 2004. | B/B | Genotype (Mutation Score) | S (0) | S (0) | S (0) | S (0) | S (0) |
(L10V/M41L,M184V/None) Oct. 14, 2004 | Phenotype (IC50, FC) | 171 nM, 23.9 | 91.7 nM, 6.8 | 43.8 nM, 64.4 | 5.47 nM, 124.3 | 3.84E–01 nM, 28.7 | ||
KRB5018 | Treatment-experienced patient infected with HIV. Treatment with AZT, ddI, 3TC, IDV, and EFV from Jul. 1998 to Dec. 2004. | B/B | Genotype (Mutation Score) | S (0) | S (0) | S (0) | R (90) | I [15] |
(L10I/M41L,L74V,M184V,L210W,T215Y,K219N/L100I,K103N) Dec. 27, 2004 | Phenotype (IC50, FC) | 44.2 nM, 6.2 | 4.83 nM, 0.4 | 2.53E–01 nM, 0.4 | 119 nM, 2704.6 | 9.20E–01 nM, 68.7 | ||
KRC2092 | Treatment-experienced patient infected with HIV. Treatment with AZT, 3TC, IDV, and EFV from Jan. 2003 to Nov. 2004. | B/B | Genotype (Mutation Score) | S (0) | S (0) | S (0) | R (80) | S (5) |
(None/D67N,M184V,L210W,T215Y/A98G,K103N,K238T) Nov. 29, 2004 | Phenotype (IC50, FC) | 81.9 nM, 11.4 | 53.4 nM, 4.0 | 1.45 nM, 2.1 | 10.5 nM, 238.6 | 5.00E–02 nM, 3.7 | ||
KRB4025 | Treatment-experienced patient infected with HIV. Treatment with AZT, LPV/RTV, ddI, and 3TC from May 2003 to Feb. 2009. | B/B | Genotype (Mutation Score) | R (145) | R (90) | I (30) | I (30) | I (30) |
(M46I,L76V,V82C,I84V,L10I,V11I/M41L,T69D,L210W,T215Y/Y181C) Feb. 9, 2009 | Phenotype (IC50, FC) | <1e–004 nM, >>> | >1000 nM, >> | 164 nM, 241.2 | 7.51 nM, 170.7 | 5.77 nM, 430.6 | ||
KRB8014 | Treatment-experienced patient infected with HIV. Treatment with AZT, IDV, 3TC, ddI, EFV, and LPV/RTV from Jun. 1998 to Mar. 2009. | D/B | Genotype (Mutation Score) | R (140) | R (150) | I (20) | R (90) | I (15) |
(M46L,I54V,L76V,V82A,L90M,L10V,K43T,A71V/M41L,L74V,M184V,L210W,T215C,K219E/L100I,K103N) Mar. 5, 2009 | Phenotype (IC50, FC) | <1e–004 nM, >>> | >1000 nM, >> | 162 nM, 238.2 | 6.34E–02 nM, 1.4 | 6.03E–02 nM, 4.5 | ||
KRC3221 | Treatment-experienced patient infected with HIV. | B/B | Genotype (Mutation Score) | S (10) | I (30) | S (0) | I (15) | S (0) |
(V82A,L10I/L210W,T215Y/K103T) Nov. 1, 2008 | Phenotype (IC50, FC) | 141 nM, 19.7 | 324 nM, 24.0 | 1.70 nM, 2.5 | 8.41E–01 nM, 19.1 | 3.04E–02 nM, 2.3 | ||
KRC0064 | Treatment-experienced patient infected with HIV. Treatment with AZT, 3TC, and LPV/RTV from Feb. 2009 to Oct. 2009. | B/B | Genotype (Mutation Score) | S (0) | S (0) | S (0) | S (0) | S (0) |
(None/None/None) Oct. 22, 2009 | Phenotype (IC50, FC) | 1.69 nM, 0.2 | 8.98E–01 nM, 0.1 | 5.87E–02 nM, 0.1 | 4.10E–01 nM,9.3 | 8.83E–02 nM,6.6 | ||
KRC4543 | Treatment-experienced patient infected with HIV. Treatment with 3TC, EFV, and AZT from May 2008 to Jan. 2009 | B/B | Genotype (Mutation Score) | I (20) | I (20) | S (0) | R (90) | I (30) |
(L90M,L10I,A71V/M41L,T69i,M184V,T215F/K101P,K103N) | Phenotype (IC50, FC) | 21.5 nM, 3.0 | 129 nM, 9.6 | 2.26 nM, 3.3 | 1.39E–01 nM, 3.2 | 7.73E–02 nM, 5.8 | ||
Jan. 8, 2009 |