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Table 2 Neutralizing antibody titers (NATs) and survival rates in mice

From: The efficacy of inactivated West Nile vaccine (WN-VAX) in mice and monkeys

Group

NATs in pooled serum a of WN-VAX immunized mice (serum dilution)

NATs in serum of of individual mouse b 24 hrs after passive immunization

Survival rate of passively immunized mice c after challenge with WNV NY99

1

2.62d

1.72d

100% (10/10)e

 

(1:1)

1.66

 
  

1.73

 
  

1.73

 
  

1.93

 

2

2.09

1.55

100% (10/10)

 

(1:4)

1.36

 
  

1.23

 
  

1.33

 
  

1.27

 

3

1.65

1.03

100% (10/10)

 

(1:16)

<1.00

 
  

<1.00

 
  

<1.00

 
  

<1.00

 

4

1.01

<1.00

30% (3/10)

 

(1:64)

<1.00

 
  

<1.00

 
  

<1.00

 
  

<1.00

 

Control

 

Not tested

0% (0/10)

  1. aused for passive immunization of mice in Groups 1, 2, 3 and 4.
  2. bOnly 5 mice per experimental group had their serum determined for NATs. These mice were not subjected to virus challenge and were used only for a representative determination of NATs in the group.
  3. cNATs of their serum were not determined because no blood sampling was done to avoid stressing the animals during virus challenge.
  4. dNAT log10.
  5. enumber enclosed in parentheses refer to the number of surviving mice/total no. of mice.
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Virology Journal

ISSN: 1743-422X