Figure 1
From: Pathogenesis of natural and experimental Pseudorabies virus infections in dogs
Gross and microscopic lesions in naturally PRV-infected dogs. A: Heart, showing ecchymoses in the epicardium; B: heart, showing an ecchymosis in the papillary muscle of the left ventricle (LV, left ventricle; MV, mitral valves); C: heart, showing focal hemorrhage (arrows) in the mitral valves (LV, left ventricle; MV, mitral valves); D: lung, focal hemorrhage; E: stomach, diffuse deep-red discoloration of the gastric mucosa as a consequence of congestion and hemorrhage; F: spleen, numerous dark-red to black, raised, soft, blood-filled areas of various sizes are incompletely contracted areas; G: thymus, evident hemorrhage; H: brainstem, showing perivascular cuffing around a small blood vessel (HE); I: hyperplasia of glial cells (HE); J: cardiac muscle, vertical section, in which the parallel arrays of myofibers are disrupted by fibrin and erythrocytes; note the myocardial fiber degeneration, necrosis with hypereosinophilia, and loss of cross-striations (HE); K: lung, hemorrhage and exudation in the lung (HE); L: brainstem, immunohistochemical detection of PRV antigen in the brainstem. DAB was used as the chromogen.