Animal
|
Infection markers in serum
*
|
Weeks after inoculation
|
---|
6
|
12
|
24
|
36
|
48
|
~150
**
|
~250
**
|
---|
108-4
|
HBV DNA
|
/#
|
-
|
-
|
±
|
±
|
-
|
-
|
|
HBsAg
|
/
|
/
|
/
|
/
|
-
|
-
|
-
|
|
HBsAb
|
/
|
/
|
/
|
/
|
+
|
±
|
-
|
|
HBeAg
|
/
|
/
|
/
|
/
|
-
|
-
|
-
|
|
HBeAb
|
/
|
/
|
/
|
/
|
-
|
-
|
-
|
|
HBcAb
|
/
|
/
|
/
|
/
|
-
|
-
|
-
|
117
|
HBV DNA
|
1.10 × 103
|
-
|
±
|
-
|
-
|
1.92 × 103
|
-
|
|
HBsAg
|
±
|
±
|
-
|
-
|
-
|
-
|
-
|
|
HBsAb
|
+
|
+
|
-
|
±
|
-
|
+
|
+
|
|
HBeAg
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBeAb
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBcAb
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
122-2
|
HBV DNA
|
-
|
±
|
-
|
-
|
-
|
-
|
-
|
|
HBsAg
|
±
|
±
|
-
|
-
|
-
|
-
|
-
|
|
HBsAb
|
+
|
+
|
±
|
±
|
-
|
+
|
+
|
|
HBeAg
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBeAb
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
|
HBcAb
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
131-3
|
HBV DNA
|
±
|
±
|
-
|
-
|
±
|
-
|
-
|
|
HBsAg
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBsAb
|
+
|
+
|
±
|
±
|
-
|
-
|
-
|
|
HBeAg
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBeAb
|
-
|
+
|
±
|
±
|
-
|
-
|
-
|
|
HBcAb
|
-
|
+
|
-
|
±
|
-
|
-
|
+
|
133-2
|
HBV DNA
|
1.24 × 103
|
3.01 × 103
|
±
|
3.5 × 103
|
-
|
-
|
-
|
|
HBsAg
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBsAb
|
+
|
+
|
±
|
-
|
-
|
-
|
-
|
|
HBeAg
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBeAb
|
+
|
+
|
±
|
-
|
-
|
-
|
-
|
|
HBcAb
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
133-3
|
HBV DNA
|
±
|
1.04 × 103
|
±
|
1.12 × 104
|
1.46 × 104
|
-
|
-
|
|
HBsAg
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBsAb
|
-
|
±
|
±
|
-
|
-
|
-
|
-
|
|
HBeAg
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBeAb
|
-
|
-
|
+
|
+
|
+
|
-
|
-
|
|
HBcAb
|
-
|
+
|
+
|
+
|
+
|
-
|
-
|
136-2
|
HBV DNA
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBsAg
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBsAb
|
-
|
±
|
+
|
+
|
±
|
+
|
±
|
|
HBeAg
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
HBeAb
|
-
|
+
|
-
|
-
|
+
|
-
|
-
|
|
HBcAb
|
-
|
+
|
-
|
+
|
+
|
-
|
-
|
137-2
|
HBV DNA
|
±
|
-
|
-
|
±
|
±
|
-
|
-
|
|
HBsAg
|
-
|
-
|
-
| |
-
|
-
|
-
|
|
HBsAb
|
-
|
-
|
+
|
-
|
+
|
+
|
+
|
|
HBeAg
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
|
HBeAb
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
|
HBcAb
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
140-3
|
HBV DNA
|
1.31 × 103
|
±
|
-
|
/
|
-
|
-
|
-
|
|
HBsAg
|
-
|
-
|
-
|
/
|
-
|
-
|
-
|
|
HBsAb
|
-
|
+
|
-
|
/
|
-
|
±
|
-
|
|
HBeAg
|
-
|
-
|
-
|
/
|
-
|
-
|
-
|
|
HBeAb
|
-
|
-
|
-
|
/
|
-
|
-
|
+
|
|
HBcAb
|
+
|
+
|
-
|
/
|
-
|
-
|
-
|
- *HBV DNA in serum was detected by FQ-PCR, the results were expressed as values of IU/ml (positive), “-” (values < 0.5 × 102 IU/ml) or “±” (values between 0.5 × 102-1.0 × 103 IU/ml). Serum HBsAg, HBsAb, HBeAg, HBeAb and HBcAb were detected by ELISA, the results were expressed as “+” (positive), “-” (negative) or “±” (between positive and negative).
- **“~150” means around 150 weeks. “~250” means around 250 weeks, the last time of detection.
-
#Not tested at this time point.