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Table 2 Serum HBV-infection markers in the tree shrews of group B

From: Chronic hepatitis B virus infection and occurrence of hepatocellular carcinoma in tree shrews (Tupaia belangeri chinensis)

Animal

Infection markers in serum *

Weeks after inoculation

6

12

24

36

48

~150 **

~250 **

108-4

HBV DNA

/#

-

-

±

±

-

-

 

HBsAg

/

/

/

/

-

-

-

 

HBsAb

/

/

/

/

+

±

-

 

HBeAg

/

/

/

/

-

-

-

 

HBeAb

/

/

/

/

-

-

-

 

HBcAb

/

/

/

/

-

-

-

117

HBV DNA

1.10 × 103

-

±

-

-

1.92 × 103

-

 

HBsAg

±

±

-

-

-

-

-

 

HBsAb

+

+

-

±

-

+

+

 

HBeAg

-

-

-

-

-

-

-

 

HBeAb

-

-

-

-

-

-

-

 

HBcAb

-

-

-

-

-

+

-

122-2

HBV DNA

-

±

-

-

-

-

-

 

HBsAg

±

±

-

-

-

-

-

 

HBsAb

+

+

±

±

-

+

+

 

HBeAg

-

-

-

-

-

-

-

 

HBeAb

-

-

-

-

-

-

+

 

HBcAb

-

-

-

-

-

-

+

131-3

HBV DNA

±

±

-

-

±

-

-

 

HBsAg

-

-

-

-

-

-

-

 

HBsAb

+

+

±

±

-

-

-

 

HBeAg

-

-

-

-

-

-

-

 

HBeAb

-

+

±

±

-

-

-

 

HBcAb

-

+

-

±

-

-

+

133-2

HBV DNA

1.24 × 103

3.01 × 103

±

3.5 × 103

-

-

-

 

HBsAg

-

-

-

-

-

-

-

 

HBsAb

+

+

±

-

-

-

-

 

HBeAg

-

-

-

-

-

-

-

 

HBeAb

+

+

±

-

-

-

-

 

HBcAb

-

+

-

-

-

-

-

133-3

HBV DNA

±

1.04 × 103

±

1.12 × 104

1.46 × 104

-

-

 

HBsAg

-

-

-

-

-

-

-

 

HBsAb

-

±

±

-

-

-

-

 

HBeAg

-

-

-

-

-

-

-

 

HBeAb

-

-

+

+

+

-

-

 

HBcAb

-

+

+

+

+

-

-

136-2

HBV DNA

-

-

-

-

-

-

-

 

HBsAg

-

-

-

-

-

-

-

 

HBsAb

-

±

+

+

±

+

±

 

HBeAg

-

-

-

-

-

-

-

 

HBeAb

-

+

-

-

+

-

-

 

HBcAb

-

+

-

+

+

-

-

137-2

HBV DNA

±

-

-

±

±

-

-

 

HBsAg

-

-

-

 

-

-

-

 

HBsAb

-

-

+

-

+

+

+

 

HBeAg

-

-

-

+

-

-

-

 

HBeAb

-

-

+

-

-

-

-

 

HBcAb

-

-

-

-

-

-

-

140-3

HBV DNA

1.31 × 103

±

-

/

-

-

-

 

HBsAg

-

-

-

/

-

-

-

 

HBsAb

-

+

-

/

-

±

-

 

HBeAg

-

-

-

/

-

-

-

 

HBeAb

-

-

-

/

-

-

+

 

HBcAb

+

+

-

/

-

-

-

  1. *HBV DNA in serum was detected by FQ-PCR, the results were expressed as values of IU/ml (positive), “-” (values < 0.5 × 102 IU/ml) or “±” (values between 0.5 × 102-1.0 × 103 IU/ml). Serum HBsAg, HBsAb, HBeAg, HBeAb and HBcAb were detected by ELISA, the results were expressed as “+” (positive), “-” (negative) or “±” (between positive and negative).
  2. **“~150” means around 150 weeks. “~250” means around 250 weeks, the last time of detection.
  3. #Not tested at this time point.
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Virology Journal

ISSN: 1743-422X