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Table 1 DENV titers a (x10 6 pfu b /ml) in the absence and presence of MB21

From: A small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture

DENV serotype c Without MB21 With MB21 d P value e
1 1.06 ± 0.03 0.52 ± 0.02 0.0028***
2 1.54 ± 0.12 0.27 ± 0.01 0.0045***
3 0.59 ± 0.01 0.14 ± 0.04 0.0065***
4 0.22 ± 0.02 0.05 ± 0.03 0.031**
  1. aTiters were determined by plaque assay on Vero cells.
  2. bPfu = plaque forming units.
  3. cThe viral strains used were: DENV-1: West Pac 74; DENV-2: S-16803; DENV-3: CH54389; and DENV-4: TVP-360.
  4. dMB21 used at 30 μM final concentration.
  5. e P values were calculated using Graphpad software; P values were either significant (**) or very significant (***).