Skip to main content

Table 1 DENV titers a (x10 6 pfu b /ml) in the absence and presence of MB21

From: A small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture

DENV serotype c

Without MB21

With MB21 d

P value e

1

1.06 ± 0.03

0.52 ± 0.02

0.0028***

2

1.54 ± 0.12

0.27 ± 0.01

0.0045***

3

0.59 ± 0.01

0.14 ± 0.04

0.0065***

4

0.22 ± 0.02

0.05 ± 0.03

0.031**

  1. aTiters were determined by plaque assay on Vero cells.
  2. bPfu = plaque forming units.
  3. cThe viral strains used were: DENV-1: West Pac 74; DENV-2: S-16803; DENV-3: CH54389; and DENV-4: TVP-360.
  4. dMB21 used at 30 μM final concentration.
  5. e P values were calculated using Graphpad software; P values were either significant (**) or very significant (***).
Back to article page

Virology Journal

ISSN: 1743-422X