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Figure 3 | Virology Journal

Figure 3

From: A small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture

Figure 3

Mode of inhibition of DENV-2 NS2b-NS3Pro by MB21. (A) Enzymatic activity of DENV-2 NS2b-NS3Pro as a function of substrate concentration in the absence (filled circles) and presence of 6 μM MB21 (empty circles). The table shows kinetic parameters in presence (E + S + I) and absence (E + S) of MB21. E, S and I denote the enzyme, DENV-2 NS2b-NS3Pro, the substrate, Bz-nKRR-AMC, and the inhibitor, MB21. (B) Lineweaver-Burke plot of DENV-2 NS2b-NS3Pro activity in the absence (filled circles) and presence of 6 μM MB21 (empty circles). Data were analyzed using GraphPad Prism software.

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Virology Journal

ISSN: 1743-422X