Inhibition of DENV-2 NS2b-NS3Pro by MB21 and
analysis of the interaction between the two. (A) Inhibition of protease activity of cloned DENV-2 NS2b-NS3Pro as a function of MB21 concentration. (B) Computer generated 2D ligand interaction picture depicting the interaction between MB21 and DENV-2 NS2b-NS3Pro. Hydrophobic residues are shown in green. (C) Interaction of MB21 at the allosteric pocket in the vicinity of the catalytic triad.