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Table 3 The most common HPV 16 E6 variants in women from Southern Mexico and risk of cervical carcinoma

From: Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico

Variants

Non-IL N (%)

LSIL N (%)

OR (CI 95%) P

HSIL N (%)

OR (CI 95%) P

SCC N (%)

OR (CI 95%) p

ADC N (%)

OR (CI 95%) P

Other epithelial tumor N (%)

Cervical carcinoma N (%)

OR (CI 95%) P

Class E-T350a

23 (23.71%)

23 (18.7%)

-

1 (5.26%)

-

4 (5.26%)

-

0 (0%) b

-

0 (0.0%)

4 (4.40%)

-

E-Prototype

17 (17.53%)

23 (18.7%)

1*

1 (5.26%)

1*

2 (2.63%)

1*

0 (0%)b

1*

-

2 (2.2%)

1*

Class E-G350

64 (65.98%)

85 (69.11%)

0.97

 

3.73

 

12.66

 

2.42

  

14.12

0.47-1.99

14 (73.68%)

0.46-30.44

49 (64.47%)

1.89-84.92

7 (53.85%)

0.25-∞

1 (50.0%)

57 (62.65%)

2.19-90.97

0.94

 

0.22

 

0.009

 

0.44

  

0.005

E-G350

39 (40.21%)

56 (45.53%)

1.01

 

2.58

 

12.56

 

1.74

  

13.25

0.47-2.17

6 (31.58%)

0.29-23.17

28 (36.84%)

1.84-85.86

3 (23.08%)

0.15-∞

-

31 (34.07%)

2.02-87.12

0.98

 

0.39

 

0.010

 

0.65

  

0.007

E-A176/G350

3 (3.09%)

5 (4.07%)

1.49

 

5.82

 

24.79

 

12.62

  

39.82

0.31-7.23

1 (5.26%)

0.28-121.37

5 (6.58%)

2.33-263.35

2 (15.38%)

0.79-∞

1 (50.0%)

8 (8.79%)

4.11-386.04

0.62

 

0.26

 

0.008

 

0.07

  

0.001

E-C188/G350

11 (11.34%)

13 (10.57%)

1.0

 

7.91

 

8.56

 

3.05

  

10.48

0.35-2.84

5 (26.32%)

0.81-77.58

8 (10.53%)

1.07-68.26

2 (15.38%)

0.23-∞

-

10 (10.99%)

1.39-78.92

0.99

 

0.08

 

0.043

 

0.40

  

0.023

Class AA-a

4 (4.12%)

11 (8.94%)

2.18

 

12.65

 

35.21

 

21.24

  

54.51

0.58-8.17

3 (15.79%)

1.02-156.20

12 (15.79%)

3.87-320.39

5 (38.46%)

1.75-∞

1 (50.0%)

18 (19.78%)

6.36-467.62

0.25

 

0.048

 

0.002

 

0.016

  

0.000

AA-a

3 (3.09%)

11 (8.94%)

3.08

 

17.40

 

43.73

 

26.69

  

69.01

0.73-13.04

3 (15.79%)

1.32-229.60

12 (15.79%)

4.55-420.56

5 (38.46%)

2.10-∞

1 (50.0%)

18 (19.78%)

7.57-628.96

0.13

 

0.03

 

0.001

 

0.01

  

0.000

Class AA-c

6 (6.19%)

3 (2.44%)

0.44

 

2.79

 

24.46

 

3.01

  

25.28

0.10-2.06

1 (5.26%)

0.15-52.20

11 (14.47%)

2.89-207.12

1 (7.69%)

0.15-∞

-

12 (13.19%)

3.12-204.74

0.30

 

0.49

 

0.003

 

0.47

  

0.002

AA-c

6 (6.19%)

3 (2.44%)

0.46

 

2.93

 

19.97

 

2.99

  

21.16

0.10-2.15

1 (5.26%)

0.16-54.90

9 (11.84%)

2.34-170.25

1 (7.69%)

0.15-∞

-

10 (10.99%)

2.59-172.56

0.32

 

0.47

 

0.006

 

0.47

  

0.004

Class Af2-a

0 (0%)

1 (0.81%)

-

0 (0%)

-

0 (0%)

-

0 (0%)

-

0 (0%)

0 (0%)

-

  1. *,Indicate reference category (E-Prototype).
  2. a ,OR was not calculated for E-T350 class because it includes reference category (E-Prototype).
  3. b,To calculate OR and CI in ADC an artificial case was created.
  4. OR: Odds ratio adjusted for age.
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Virology Journal

ISSN: 1743-422X