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Table 4 Frequencies of subject-reported symptoms, physician-reported signs and pyrexia from cohorts 1 to 3

From: Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans

  Cohort 1 (N = 5) Cohort 2 (N = 12) Cohort 3 (N = 12) All (N = 29)
Subject-reported symptoms n % n % n % n %
Headache 2 40.0 4 33.3 7 58.3 13 44.8
Nasal stuffiness/congestion 2 40.0 5 41.7 5 41.7 12 41.4
Sore throat 1 20.0 5 41.7 5 41.7 11 37.9
Sneezing 1 20.0 4 33.3 6 50.0 11 37.9
Cough 1 20.0 4 33.3 5 41.7 10 34.5
Hot/feverish/chills/rigor 1 20.0 5 41.7 4 33.3 10 34.5
Runny nose 1 20.0 3 25.0 5 41.7 9 31.0
Musculoskeletal ache 2 40.0 3 25.0 3 25.0 8 27.6
Fatigue 2 40.0 3 25.0 3 25.0 8 27.6
Breathing difficulty 1 20.0 2 16.7 3 25.0 6 20.7
Diarrhoea 0 0.0 4 33.3 2 16.7 6 20.7
Earache 0 0.0 3 25.0 2 16.7 5 17.2
Facial or eye pain 0 0.0 2 16.7 3 25.0 5 17.2
Hoarseness 1 20.0 1 8.3 1 8.3 3 10.3
Nausea/vomiting 0 0.0 2 16.7 1 8.3 3 10.3
Wheezy chest 0 0.0 0 0.0 1 8.3 1 3.4
Physician-reported signs n % n % n % n %
Pharyngitis 1 20.0 7 58.3 10 83.3 18 62.1
Nasal discharge 0 0.0 8 66.7 8 66.7 16 55.2
Otitis 0 0.0 0 0.0 6 50.0 6 20.7
Sinus tenderness 0 0.0 3 25.0 2 16.7 5 17.2
New wheezes/crackles/rhonchi 0 0.0 0 0.0 2 16.7 2 6.9
Percussion 0 0.0 0 0.0 0 0.0 0 0.0
Pyrexia n % n % n % n %
Temperature >37.7°C 2 40.0 3 25.0 2 16.7 5 17.2