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Table 4 Frequencies of subject-reported symptoms, physician-reported signs and pyrexia from cohorts 1 to 3

From: Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans

 

Cohort 1 (N = 5)

Cohort 2 (N = 12)

Cohort 3 (N = 12)

All (N = 29)

Subject-reported symptoms

n

%

n

%

n

%

n

%

Headache

2

40.0

4

33.3

7

58.3

13

44.8

Nasal stuffiness/congestion

2

40.0

5

41.7

5

41.7

12

41.4

Sore throat

1

20.0

5

41.7

5

41.7

11

37.9

Sneezing

1

20.0

4

33.3

6

50.0

11

37.9

Cough

1

20.0

4

33.3

5

41.7

10

34.5

Hot/feverish/chills/rigor

1

20.0

5

41.7

4

33.3

10

34.5

Runny nose

1

20.0

3

25.0

5

41.7

9

31.0

Musculoskeletal ache

2

40.0

3

25.0

3

25.0

8

27.6

Fatigue

2

40.0

3

25.0

3

25.0

8

27.6

Breathing difficulty

1

20.0

2

16.7

3

25.0

6

20.7

Diarrhoea

0

0.0

4

33.3

2

16.7

6

20.7

Earache

0

0.0

3

25.0

2

16.7

5

17.2

Facial or eye pain

0

0.0

2

16.7

3

25.0

5

17.2

Hoarseness

1

20.0

1

8.3

1

8.3

3

10.3

Nausea/vomiting

0

0.0

2

16.7

1

8.3

3

10.3

Wheezy chest

0

0.0

0

0.0

1

8.3

1

3.4

Physician-reported signs

n

%

n

%

n

%

n

%

Pharyngitis

1

20.0

7

58.3

10

83.3

18

62.1

Nasal discharge

0

0.0

8

66.7

8

66.7

16

55.2

Otitis

0

0.0

0

0.0

6

50.0

6

20.7

Sinus tenderness

0

0.0

3

25.0

2

16.7

5

17.2

New wheezes/crackles/rhonchi

0

0.0

0

0.0

2

16.7

2

6.9

Percussion

0

0.0

0

0.0

0

0.0

0

0.0

Pyrexia

n

%

n

%

n

%

n

%

Temperature >37.7°C

2

40.0

3

25.0

2

16.7

5

17.2