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Table 3 Summary of lab-confirmed illness

From: Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans

Inoculum dose dilution a Number of subjects % rRT-PCR positive b % Sero-converted c % Clinical illness (mild) d % Clinical illness (mod-erate) e % Lab-confirmed mild illness f % Lab-confirmed moderate illness f
1:1000 5 20 40 40 20 20 20
1:100 12 41.6 50 75 41.6 66 41.6
1:10 12 75 50 100 58.3 75 50
  1. aNeat virus was 3.5 × 107 TCID50.
  2. bAssessed using a rRT-PCR assay.
  3. cSeroconversion defined as a fold increase in serum HI titres of ≥4.
  4. dMild clinical illness defined as one mild physician-reported sign or subject-reported symptom.
  5. eModerate clinical illness defined as one moderate physician-reported sign or subject-reported symptom.
  6. fLab-confirmed illness defined as mild or moderate clinical illness + positive rRT-PCR result or seroconversion or both.