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Table 2 The maximum recorded symptom or sign present during the quarantine phase in cohort 3 (N = 12)

From: Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans

  Mild Moderate Severe All
Subject-reported symptoms n % n % n % n %
Headache 4 33.3 2 16.7 1 8.3 7 58.3
Nasal stuffiness/congestion 3 25.0 2 16.7 0 0 5 41.7
Sore throat 3 25.0 2 16.7 0 0 5 41.7
Sneezing 3 25.0 3 25.0 0 0 6 50.0
Cough 2 16.7 2 16.7 1 8.3 5 41.7
Hot/feverish/chills/rigor 3 25.0 1 8.3 0 0 4 33.3
Runny nose 4 33.3 0 0 1 8.3 5 41.7
Musculoskeletal ache 1 8.3 0 0 2 16.6 3 25.0
Fatigue 2 16.7 1 8.3 0 0 3 25.0
Breathing difficulty 3 16.7 0 0 0 0 3 25.0
Diarrhoea 1 8.3 1 8.3 0 0 2 16.7
Earache 2 16.7 0 0 0 0 2 16.7
Facial or eye pain 2 16.7 0 0 1 8.3 3 25.0
Hoarseness 1 8.3 0 0 0 0 1 8.3
Nausea/vomiting 1 8.3 0 0 0 0 1 8.3
Wheezy chest 1 8.3 0 0 0 0 1 8.3
Physician-reported signs n % n % n % n %
Pharyngitis 10 83.3 0 0 0 0 10 83.3
Nasal discharge 3 25.0 3 25.0 2 16.6 8 66.7
Otitis 2 16.6 4 33.3 0 0 6 50.0
Sinus tenderness 2 16.6 0 0 0 0 2 16.7
New wheezes/crackles/rhonchi 1 8.3 1 8.3 0 0 2 16.7
Percussion 0 0 0 0 0 0 0 0