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Table 2 The maximum recorded symptom or sign present during the quarantine phase in cohort 3 (N = 12)

From: Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans

 

Mild

Moderate

Severe

All

Subject-reported symptoms

n

%

n

%

n

%

n

%

Headache

4

33.3

2

16.7

1

8.3

7

58.3

Nasal stuffiness/congestion

3

25.0

2

16.7

0

0

5

41.7

Sore throat

3

25.0

2

16.7

0

0

5

41.7

Sneezing

3

25.0

3

25.0

0

0

6

50.0

Cough

2

16.7

2

16.7

1

8.3

5

41.7

Hot/feverish/chills/rigor

3

25.0

1

8.3

0

0

4

33.3

Runny nose

4

33.3

0

0

1

8.3

5

41.7

Musculoskeletal ache

1

8.3

0

0

2

16.6

3

25.0

Fatigue

2

16.7

1

8.3

0

0

3

25.0

Breathing difficulty

3

16.7

0

0

0

0

3

25.0

Diarrhoea

1

8.3

1

8.3

0

0

2

16.7

Earache

2

16.7

0

0

0

0

2

16.7

Facial or eye pain

2

16.7

0

0

1

8.3

3

25.0

Hoarseness

1

8.3

0

0

0

0

1

8.3

Nausea/vomiting

1

8.3

0

0

0

0

1

8.3

Wheezy chest

1

8.3

0

0

0

0

1

8.3

Physician-reported signs

n

%

n

%

n

%

n

%

Pharyngitis

10

83.3

0

0

0

0

10

83.3

Nasal discharge

3

25.0

3

25.0

2

16.6

8

66.7

Otitis

2

16.6

4

33.3

0

0

6

50.0

Sinus tenderness

2

16.6

0

0

0

0

2

16.7

New wheezes/crackles/rhonchi

1

8.3

1

8.3

0

0

2

16.7

Percussion

0

0

0

0

0

0

0

0