Health care professionals at risk of infection with Borna disease virus – evidence from a large hospital in China (Chongqing)

Table 1 Demographic variables and BDV infection prevalence in study participants

	I, MDD outpatients	II, Hospital personnel	III, Healthy, controls	P -value
				Group I vs. II	Group I vs. III	Group II vs. III	All three groups
Sample size	534	615	380
Age (year) ^{a, b}	35.99 ± 12.23	39.28 ± 11.61	35.58 ± 10.86	0.000	0.885	0.000	0.000^e
<25	116	38	57
25-39	217	284	193
40-54	147	226	105
55-70	54	56	25
>70	0	11	0
Sex (M/F) ^c	187/347	182/433	160/220	0.049	0.030	0.000
HDRS score ^a,d	20.58 ± 7.00	2.2 ± 0.8	1.2 ± 1.0	0.000	0.000	0.143
CIC+ (%) ^c	97 (18.2%)	134 (21.8%)	42 (11.1%)	0.001	0.024	0.000
p24 RNA+ (%) ^c	27 (5.1%),	50 (8.1%),	8 (2.1%),	0.038	0.022	0.000
CIC+ and p24 RNA + ^c	21 (3.9%),	48 (7.8%)	5 (1.3%)	0.006	0.019	0.000
CIC+ and/or p24 RNA + ^c	103 (19.3%),	136 (22.1%),	45 (11.8%),	0.239	0.003	0.000
CIC- and p24 RNA+	6	2	3
CIC level							0.197^f
Negative and borderline	437	454	332
Weakly/1+ positive	82	134	42
2+ positive	14	23	6
3+ and 4+ positive	1	4	0
Antibody+/CIC+	5/50	3/50	4/40
Antibody+/CIC+	0/50	1/50	1/40

Abbreviations: MDD major depressive disorder, M male, F female, HDRS Hamilton Depression Rating Scale, CIC circulating immune complexes, p24 BDV phosphoprotein 24, RNA ribonucleic acid. ^aValues expressed as means ± SDs.,^bMann-Whitney test,^cChi-square test,^dOne-way ANOVA,^eKruskal-Wallis test,^fSpearman correlation.

ISSN: 1743-422X