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Figure 2 | Virology Journal

Figure 2

From: Differential regulation of cytotoxicity pathway discriminating between HIV, HCV mono- and co-infection identified by transcriptome profiling of PBMCs

Figure 2

Enrichment plot and heatmap for NK cell mediated cytotoxicity pathway detected by GSEA. A. Enrichment plot for the comparison of HCV versus HH and the corresponding heat map of the core enrichment genes. Enrichment plot: Bottom, plot of the ranked list of all genes. Y axis, value of the ranking metric; X axis, the rank for all genes. Genes whose expression levels are most closely associated with the HCV or HH group get the highest metric scores with positive or negative sign, and are located at the left or right edge of the list. Middle, the location of genes from the cytotoxicity pathway within the ranked list. Top, the running enrichment score for the gene set as the analysis walks along the ranked list. The score at the peak of the plot is the enrichment score (ES) for this gene set and those genes appear before or at the peak are defined as core enrichment genes for this gene set. Heat map: The genes that contribute most to the ES, i.e., genes that appear in the ranked list before or at the peak point of ES, are defined as core enrichment genes. Rows, genes; columns, samples. Range of colors (red to blue) shows the range of expression values (high to low). B. Enrichment plot for the comparison of HIV versus HH and the corresponding heat map of the core enrichment genes.

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