Neutralization of IL-22 exacerbated myocardial fibrosis at stages of AVMC and chronic myocarditis. A. Relative cardiac expression and plasma levels of COL1-A1 detected at week 2 and 12, measured by RT-PCR and ELISA. B. Up-regulation of cardiac expression of COL3-A1 in anti-IL-22 Ab treated mice. C. The ratio of MMP9/TIMP-1 mRNA. D-E. Higher MMP9 and lower TIMP-1 detected in anti-IL-22 Ab treated mice. *p < 0.05, **p < 0.01. Data are the means ± SD.