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Figure 7 | Virology Journal

Figure 7

From: IL-22-producing Th22 cells play a protective role in CVB3-induced chronic myocarditis and dilated cardiomyopathy by inhibiting myocardial fibrosis

Figure 7

Neutralization of IL-22 exacerbated myocardial fibrosis at stages of AVMC and chronic myocarditis. A. Relative cardiac expression and plasma levels of COL1-A1 detected at week 2 and 12, measured by RT-PCR and ELISA. B. Up-regulation of cardiac expression of COL3-A1 in anti-IL-22 Ab treated mice. C. The ratio of MMP9/TIMP-1 mRNA. D-E. Higher MMP9 and lower TIMP-1 detected in anti-IL-22 Ab treated mice. *p < 0.05, **p < 0.01. Data are the means ± SD.

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Virology Journal

ISSN: 1743-422X