Neutralization of IL-22 exacerbated the severity of AVMC and chronic myocarditis. A. Survival rate of anti-IL-22 Ab treated mice at week 2 and 12 after neutralization of IL-22. B. CVF of mice in anti-IL-22 Ab subgroup at week 12. C. Representative myocardial fibrosis images in anti-IL-22 Ab, IgG and PBS treated mice at week 2 and 12 (Masson’s Trichrome, original magnification × 100).