Aggravated myocardial fibrosis from AVMC to DCM. A. Cardiac expression of COL1-A1 was investigated by RT-PCR, and the level of circulating protein was measured by ELISA. B. Cardiac COL3-A1 expression in mice treated with virus. C-D. Cardiac MMP9 and TIMP-1 expression and circulating protein. E. The ratio of MMP9/TIMP-1 mRNA. F. CVF of mice receiving virus showing a progressive increase in the course from AVMC to DCM. *p < 0.05, **p < 0.01. Data are means ± SD.