Oncolytic parvoviruses: from basic virology to clinical applications

Table 1 Antineoplastic effects of H-1PV on different human tumor entities

Tumor entity	*In vitro* system	*In vitro* effect	*In vivo* system	*In vitro* effect	References
Glioblastoma and gliosarcoma	Cell lines and primary cells	Dose-dependent killing at low MOIs	Immunocompetent Wistar rats; Nude rats	Complete tumor regression and increased animal survival	[77,79]
Neuroblastoma	Cell lines	Highly efficient cell killing	N.D.	N.D.	[48]
Medulloblastoma	Cell lines	40-100% cell lysis	N.D.	N.D.	[84]
Burkitt’s lymphoma	EBV positive and negative cell lines	80-100% cell death	SCID mice	Tumor regression and significant prolongation of animal survival	[85]
Breast	Cell lines and primary cells	20-80% cell death	Nude mice	Inhibition of tumor formation; tumor regression	[86,88,89]
Pancreatic carcinoma	Cell lines and short-term cultures	20-100% cell killing	SCID mice; Nude rats	Tumor regression	[13,91]
Cervical carcinoma	Cell lines	40-100% cell lysis	SCID mice; Nude rats	Tumor regression	[13,96]
Gastric tumors	Cell lines	20-80% cell death	Nude mice	Inhibition of tumor formation	[98]
Melanoma	Cell lines	Cell killing	N.D.	N.D.	[64]
Hepatoma	Cell lines	80% reduction of metabolic activity	Nude mice	Inhibition of tumor formation	[99]
Colon	Cell lines	Limited virus replication and cytotoxicity	N.D.	N.D.	[66,102]

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