Table 2 Pathogenicity of the SW/3/06 virus in different mammalian species
From: The pathogenicity of swan derived H5N1 virus in birds and mammals and its gene analysis
Species (inoculation route) | Mortalitya | MDT (days) | Dose (EID50)b | Antibody titer on indicated day post-infectionc | ||
|---|---|---|---|---|---|---|
14 | 21 | 28 | ||||
BALB/c mice (i.n.) | 5/5 | 2.4 | 104.0 | ND | ND | ND |
BALB/c mice (i.m.) | 5/5 | 2.8 | 104.0 | ND | ND | ND |
Guinea pigs (i.n.) | 0/5 | >14.0 | 104.3 | 5.0 ± 1.0 | 5.3 ± 0.6 | 5.7 ± 0.6 |
Guinea pigs (i.m.) | 0/5 | >14.0 | 104.3 | 4.7 ± 1.1 | 4.7 ± 0.6 | 5.3 ± 0.6 |
Guinea pigs (i.n.) | 0/3 | >14.0 | 106.0 | 5.0 ± 0.0 | 5.7 ± 0.6 | 6.0 ± 0.0 |
Guinea pigs (contact) | 0/3 | >14.0 | – | < 1.0 | < 1.0 | < 1.0 |
Large White pigs (i.n.) | 0/5 | >14.0 | 105.3 | 3.7 ± 0.6 | 4.0 ± 0.0 | 4.7 ± 0.6 |
Large White pigs (i.m.) | 0/5 | >14.0 | 105.3 | 3.0 ± 0.0 | 3.3 ± 0.6 | 4.0 ± 0.0 |
Scottish Fold cats (i.n.) | 0/3 | >14.0 | 104.6 | 7.0 ± 1.0 | 8.3 ± 1.1 | 8.7 ± 0.6 |
Scottish Fold cats (i.t.) | 0/3 | >14.0 | 104.6 | 7.0 ± 1.7 | 8.0 ± 0.0 | 8.3 ± 0.6 |
Beagle dogs (i.n.) | 3/3 | 2.3 | 104.6 | ND | ND | ND |
Beagle dogs (i.t.) | 3/3 | 4.7 | 104.6 | ND | ND | ND |