The diversity of human papillomavirus infection among human immunodeficiency virus-infected women in Yunnan, China

Zhang, Hong-Yun; Fei, Man-Dong; Jiang, Yong; Fei, Qiu-Yue; Qian, Hong; Xu, Lin; Jin, Yu-Ni; Jiang, Cheng-Qin; Li, Hai-Xia; Tiggelaar, Sarah M; Smith, Jennifer S; Sahasrabuddhe, Vikrant V; Qiao, You-Lin

doi:10.1186/s12985-014-0202-3

Virology Journal

Table 1 Prevalence of HPV genotypes stratified by composite cytology-colposcopic-histopathological CIN diagnoses

From: The diversity of human papillomavirus infection among human immunodeficiency virus-infected women in Yunnan, China

HPV infection groupings/types	Total n (%)	No CIN (N = 251) n (%)	CIN1 (N = 22) n (%)	CIN2+ (N = 28) n (%)	χ ² _trend	p
Overall HPV infection	131(43.5)	93(37.1)	14(63.6)	24(85.7)	28.04	*<0.001*
Carcinogenic HPV infection
Single carcinogenic HPV type	80(26.6)	57(22.7)	7(31.8)	16(57.1)	26.19	*<0.001*
Multiple carcinogenic HPV types	33(11.0)	21(8.4)	4(18.2)	8(28.6)	19.59	*<0.001*
Possibly carcinogenic HPV infection	15(5.0)	8(3.2)	5(22.7)	2(7.1)	4.84	*0.035* ^a
Non-carcinogenic/unknown carcinogenic HPV infection	34(11.3)	26(10.4)	6(27.3)	2(7.1)	0.12	0.768^a
Individual HPV genotypes:
Carcinogenic HPV genotypes
HPV16	18(6.0)	9(3.6)	1(4.6)	8(28.6)	23.71	*<0.001* ^a
HPV18	19(6.3)	14(5.6)	1(4.6)	4(14.3)	2.46	0.121^a
HPV31	9(3.0)	4(1.6)	2(9.1)	3(10.7)	9.70	*0.008* ^a
HPV33	16(5.3)	11(4.4)	2(9.1)	3(10.7)	2.59	0.141^a
HPV35	10(3.3)	7(2.8)	3(13.6)	0(0.0)	0.05	1.000^a
HPV39	1(0.3)	1(0.4)	0(0.0)	0(0.0)	0.18	1.000^a
HPV45	2(0.7)	2(0.8)	0(0.0)	0(0.0)	0.36	0.878^a
HPV51	2(0.7)	2(0.8)	0(0.0)	0(0.0)	0.36	0.878^a
HPV52	22(7.3)	14(5.6)	1(4.6)	7(25.0)	11.18	*0.003* ^a
HPV56	16(5.3)	14(5.6)	2(9.1)	0(0.0)	0.80	0.433^a
HPV58	20(6.6)	13(5.2)	2(9.1)	5(17.9)	6.56	*0.016* ^a
HPV59	6(2.0)	4(1.6)	1(4.6)	1(3.6)	0.94	0.556^a
HPV68	16(5.3)	14(5.6)	1(4.6)	1(3.6)	0.23	0.695^a
Possibly carcinogenic HPV genotypes
HPV53	7(2.3)	4(1.6)	3(13.6)	0(0.0)	0.54	0.561^a
HPV66	6(2.0)	3(1.2)	1(4.6)	2(7.1)	5.32	*0.038* ^a
HPV73	2(0.7)	1(0.4)	1(4.6)	0(0.0)	0.31	1.000^a
HPV82	0(0.0)	0(0.0)	0(0.0)	0(0.0)	-	-
Non-carcinogenic/unknown carcinogenic HPV genotypes
HPV6	2(0.7)	1(0.4)	1(4.6)	0(0.0)	0.31	1.000^a
HPV11	1(0.3)	0(0.0)	1(4.6)	0(0.0)	1.45	0.166^a
HPV42	9(3.0)	6(2.4)	2(9.1)	1(3.6)	0.84	0.442^a
HPV43	25(8.3)	20(8.0)	4(18.2)	1(3.6)	0.03	1.000^a
HPV44	0(0.0)	0(0.0)	0(0.0)	0(0.0)	-	-
HPV83	3(1.0)	3(1.2)	0(0.0)	0(0.0)	0.54	0.847^a

^aFisher’s exact test. Statistically significant (p < 0.05) estimates are bolded and italicized. CIN, cervical intraepithelial neoplasia. CIN2+, cervical intraepithelial neoplasia grade 2 or worse. HPV, human papillomavirus.

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