From: Antiviral effects against EV71 of pimprinine and its derivatives isolated from Streptomyces sp
Tested compound | Â | CVB3 | HSV-1 | ADV-7 | H1N1 |
---|---|---|---|---|---|
 | CC50a | 443 ± 35e | 443 ± 35 | 1140 ± 181 | 899 ± 56 |
Pimprinine | EC50b | 95 ± 16 | 160 ± 18 | 150 ± 10 | — |
 | EC90c | —f | — | 266 ± 14 | — |
 | SId | 5 | 3 | 8 | — |
 | CC50 | 256 ± 49 | 256 ± 49 | 750 ± 30 | 577 ± 73 |
Pimprinethine | EC50 | 22 ± 4 | 45 ± 3 | 33 ± 6 | — |
 | EC90 | 58 ± 9 | — | 63 ± 5 | — |
 | SI | 12 | 6 | 23 | — |
 | CC50 | 72 ± 8 | 72 ± 8 | 217 ± 4 | 212 ± 18 |
WS-30581 A | EC50 | 14 ± 4 | 18 ± 2 | 17 ± 18 | 38 ± 7 |
 | EC90 | 39 ± 4 | — | 43 ± 3 | — |
 | SI | 5 | 4 | 13 | 6 |
 | CC50 | 83 ± 6 | 83 ± 6 | 354 ± 14 | 215 ± 28 |
WS-30581 B | EC50 | 12 ± 2 | 14 ± 4 | 15 ± 2 | 24 ± 5 |
 | EC90 | 42 ± 6 | — | 48 ± 6 | — |
 | SI | 7 | 6 | 24 | 9 |
 | CC50 | 1311 ± 385 |  | 1516 ± 243 |  |
Ribaviring | EC50 | 90 ± 10 |  | 116 ± 19 |  |
 | EC90 | 103 ± 17 |  | 132 ± 22 |  |
 | SI | 15 |  | 13 |  |
 | CC50 |  | >2000 |  |  |
Acyclovirh | EC50 |  | 11 ± 1 |  |  |
 | EC90 |  | 24 ± 5 |  |  |
 | SI |  | >181 |  |  |
 | CC50 |  |  |  | >2000 |
Amantadinei | EC50 |  |  |  | 73 ± 8 |
 | EC90 |  |  |  | 90 ± 12 |
 | SI |  |  |  | >27 |