Figure 7From: Antiviral effects against EV71 of pimprinine and its derivatives isolated from Streptomyces spAntiviral activity of pimprinine, pimprinethine, WS-30581 A and WS-30581 B against CVB3, ADV-7 and HSV-1. The Hep-2 and HeLa cells were left untreated (A) or infected with 100 TCID50 of CVB3, ADV-7 and HSV-1, after virus inoculation, the infected cells were mixed without (B) or with 160 μM pimprinine (C), 80 μM pimprinethine (D), 40 μM WS-30581 A (E) or 40 μM WS-30581 B (F) for 1 h at 37°C respectively, the inocula were aspirated and the cells were further incubated with DMEM/tested compounds at 37°C, 5% CO2 for 48 h, the antiviral effects were observed with respect to cellular morphology.Back to article page