Anti-herpes virus activities of bioactive fraction and isolated pure constituent of Mallotus peltatus: an ethnomedicine from Andaman Islands

Table 1 Assessment of Anti-HSV activity of M. peltata crude methanolic extract and its constituents by MTT assay

Test drug	CC₅₀^a	HSV-1 F at MOI: 0.5		HSV-2 G at MOI: 0.5
Test drug	CC₅₀^a	Antiviral activity (EC₅₀^b)	Selectivity index (SI)^c	Antiviral activity (EC₅₀^b)	Selectivity index (SI)^c
Crude methanolic extract	452	57.5 ± 2.45	7.86	61.2 ± 3.1	7.38
Fraction A	174	7.8 ± 1.6	22.3	8.2 ± 1.8	21.21
Fraction B	215	105.0 ± 5.7	2.04	120.0 ± 7.2	1.79
Ursolic acid (isolated)	110	5.5 ± 0.54	20	5.8 ± 1.1	18.97
Acyclovir	130	2.1 ± 0.1	61.9	2.9 ± 0.1	44.8

^a The 50% cytotoxic concentration for Vero cells in μg/ml.
^b Concentration of compound (μg/ml) producing 50% inhibition of virus induced CPE of three separate experiments.
^c Selectivity index (SI) = CC₅₀/EC₅₀.

ISSN: 1743-422X