The new temperature-sensitive mutation PA-F35S for developing recombinant avian live attenuated H5N1 influenza vaccine

Table 2 Protective efficacy of the live attenuated H5N1 influenza vaccine in chickens

Vaccine groups^#	Challengingvirus	Positive/total No. (HI antibody, log₂)before challenge	Death rate	Shedding/total (log₁₀EID₅₀/ml ± SE)
Vaccine groups^#	Challengingvirus	Positive/total No. (HI antibody, log₂)before challenge	Death rate	trachea	cloacal
ts-C4/W1	C4	0/6	6/6^$	ND (dead^&)	ND (dead)
	D6	0/6	6/6	ND (dead)	ND (dead)
C4/W1-PA(F35S)	C4	6/6^* (2.3)	0/6	0/6	0/6
	D6	5/6 (2.6)	0/6	0/6	0/6
PBS	C4	0/6	6/6	ND (dead)	ND (dead)
	D6	0/6	6/6	ND (dead)	ND (dead)

ISSN: 1743-422X