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Table 5 Changes in biophysical properties of positively-selected or “predictive” amino acids

From: Subtype- and antigenic site-specific differences in biophysical influences on evolution of influenza virus hemagglutinin

  aa Δabs ΔΔASAtot ΔΔASAnp ΔΔASApol ΔQ
Positively Selected in H1.a,b 86c, 98d, 144, 163, 165, 189, 190, 225 p < 0.001e NS p < 0.05 NS p < 0.001
“Predictive” in H3f 121, 124, 133, 135, 138, 142, 145, 156, 158, 186, 190g, 193, 194g, 197, 201, 226, 262h, 275 p < 0.001 NS NS NS NS
Directionally selected in H3.i,b 45, 135, 145, 155, 158, 229, 248 p < 0.001 NS NS NS p < 0.01
  1. aSee [17]
  2. bAmino acid numbers converted to conform to system described in Table 2
  3. cBolded numbers indicate that amino acid is defined as an epitope residue in our analysis (see Table 2)
  4. dSolvent exposed at the rear of the H1 monomer
  5. eStatistical comparison to non-epitope residues from HA1 (Kruskal Wallis one-way ANOVA (non-parametric) with Dunn’s post-test)
  6. fSee [33]
  7. gReceptor binding site residue
  8. hSolvent exposed on edge of monomer
  9. iSee [34] Residues not in HA1 are excluded from this analysis