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Table 3 Statistical comparison of antigenic sites to non-antigenic residues

From: Subtype- and antigenic site-specific differences in biophysical influences on evolution of influenza virus hemagglutinin

Antigenic Sitea

pb antigenic site vs. non-antigenic site residues

Δabs

ΔΔASAtot

ΔΔASAnp

ΔΔASApol

ΔQ

H1

Ca2

p < 0.01

NS

NS

NS

p < 0.05

Sb

p < 0.001

NS

NS

NS

NS

Sa

NS

NS

NS

NS

NS

H1C

p < 0.001

NS

NS

p < 0.05

NS

Ca1

p < 0.05

p < 0.001

NS

NS

NS

Cb

p < 0.001

p < 0.05

NS

p < 0.01

NS

H3

A

p < 0.001

NS

NS

NS

NS

B

p < 0.001

NS

NS

NS

NS

C

p < 0.001

NS

NS

NS

NS

D

p < 0.001

NS

NS

NS

NS

E

p < 0.01

NS

NS

NS

NS

B

BA

p < 0.001

p < 0.001

p < 0.001

p < 0.001

p < 0.01

BB1

p < 0.001

p < 0.01

p < 0.001

p < 0.01

p < 0.001

BB2

p < 0.001

p < 0.01

p < 0.001

p < 0.01

p < 0.01

BC

p < 0.001

p < 0.01

p < 0.01

p < 0.01

p < 0.05

BD

p < 0.001

p < 0.001

p < 0.001

p < 0.001

p < 0.01

BE

p < 0.001

p < 0.05

p < 0.01

NS

p < 0.05

  1. aSee Table 2
  2. bStatistics: Kruskal Wallis one-way ANOVA (non-parametric) with Dunn’s post-test
  3. cNon-antigenic site residues are all residues in HA1 not assigned to a particular antigenic site