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Table 3 Statistical comparison of antigenic sites to non-antigenic residues

From: Subtype- and antigenic site-specific differences in biophysical influences on evolution of influenza virus hemagglutinin

Antigenic Sitea pb antigenic site vs. non-antigenic site residues
Δabs ΔΔASAtot ΔΔASAnp ΔΔASApol ΔQ
H1
Ca2 p < 0.01 NS NS NS p < 0.05
Sb p < 0.001 NS NS NS NS
Sa NS NS NS NS NS
H1C p < 0.001 NS NS p < 0.05 NS
Ca1 p < 0.05 p < 0.001 NS NS NS
Cb p < 0.001 p < 0.05 NS p < 0.01 NS
H3
A p < 0.001 NS NS NS NS
B p < 0.001 NS NS NS NS
C p < 0.001 NS NS NS NS
D p < 0.001 NS NS NS NS
E p < 0.01 NS NS NS NS
B
BA p < 0.001 p < 0.001 p < 0.001 p < 0.001 p < 0.01
BB1 p < 0.001 p < 0.01 p < 0.001 p < 0.01 p < 0.001
BB2 p < 0.001 p < 0.01 p < 0.001 p < 0.01 p < 0.01
BC p < 0.001 p < 0.01 p < 0.01 p < 0.01 p < 0.05
BD p < 0.001 p < 0.001 p < 0.001 p < 0.001 p < 0.01
BE p < 0.001 p < 0.05 p < 0.01 NS p < 0.05
  1. aSee Table 2
  2. bStatistics: Kruskal Wallis one-way ANOVA (non-parametric) with Dunn’s post-test
  3. cNon-antigenic site residues are all residues in HA1 not assigned to a particular antigenic site
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