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Table 2 Amino acids assigned to antigenic sites

From: Subtype- and antigenic site-specific differences in biophysical influences on evolution of influenza virus hemagglutinin

H1a
Ca2 b Sb Sa H1C c Ca1 Cb
132bd,e, 133, (140), (143), 144, (145), 149, (224), 225 156f, (159)g, 189–90, 192–3, (196), 197, (198) (128), 129, 163, 165, (166–7), 247-8 86, 272–7, 279–82, 286 (169), 173, (207), 212, 240, 241, 242, 243-5 51, (74–5), 77, (78–9), (117), 149, 255–6, 259-66
H3 h
A B C D E
121, 122, (123), 124, (125), 126, (127), (129), 131, (132), 133, (134), 135, (136), 137–8, 140, 142, (143), 144–5, (146), 155, 156, (157), 158–60, 186, 188–9, (190), 192, 193, (194), (196), 197, 198–9, 246-7 49, 50, 53–4, 271, 273, 275, 276, 278 167, 201–2, (203–6), 207, 214, 216, (217– 8), 219–20, 222–3, 225–7, 242 62, (63), 75, 78, (79–82), 83, 91–2, 94
B i
BA BB1 j BB2 9 BC 3 BD BE
136-7, 141, 146, (147), 148–9, 150, 154 194, 195, 196, 197, 199, 200, 205-6 162,162a-c, 163, (164), 165 47-8, 80–1, 116, 276, 281 121-2, 125, 126–7, 129, 179–80, 181, 248–9, 252-5 56, 58, 68–9, 71, 73, 75, 76
  1. aH1 numbered according to the amino acid position in A/Puerto Rico/8/34/Mount Sinai.
  2. bResidues showing rates of change in the top 25% of all residues were assigned to previously described epitopes [7, 23, 24].
  3. cNot defined in prior studies.
  4. dAmino acid 132a deleted in A/Puerto Rico/8/34/Mount Sinai, but present in other strains prior to 1997.
  5. eResidues assigned to this epitope in this work only are italicized.
  6. fResidues assigned to this epitope in this work and in previous studies are underlined.
  7. gResidues assigned to this epitope in previous studies not meeting our inclusion criteria are enclosed in parentheses.
  8. hH3 HA residues numbered as for mature HA1 of A/Aichi/2/1968.
  9. iInfluenza B HA residues numbered as for B/Lee/40.
  10. jPrevious studies define a single epitope at the top of influenza B HA [24], but we have elected to divide this into two based on apparent functional differences based on the pattern of biophysical changes we observe.
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