Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications

Table 3 Data analysis of the clinical neurological damage caused by different pathogens

	EV71	CA16	OE	p value	Total
Total (n)	65(70.7%)	19(20.7%)	8(8.7%)		92
Encephalitis (n) ^#	39(60%)	16(82.4%)	6(75%)	0.125	61(66.3%)
Acute flaccid paralysis (n) ^#	2(3%)	1(5.3%)	0	0.772	3(3.3%)
Brainstem encephalitis (n) ^#	8(12.3%)	2(1.1%)	0	0.572	10(10.9%)
Neurogenic pulmonary edema (n) ^#	11(16.9%)	0	1(12.5%)	0.047	11(12%)
Neurologic shock (n) ^#	5(7.7%)	0	1(12.5%)	0.215	6(6.5%)
Limb shaking (n)	51(78.5%)	15(78.9%)	6(75%)	0.973	72(78.3%)
Convulsion (n)	21(32.3%)	4(21.1%)	2(25%)	0.613	27(29.3%)
Vomiting (n)	42(64.6%)	16(84.2%)	7(87.5%)	0.141	65(70.7%)
Fatigue (n)	47(72.3%)	17(89.5%)	5(62.5%)	0.219	69(75%)
Coma (n)	24(36.9%)	2(10.5%)	1(12.5%)	0.046	27(29.3%)
Limb movement disorder (n)	34(52.3%)	3(15.8%)	2(25%)	0.010	39(42.4%)
Urinary retention (n)	31(47.7%)	6(31.6%)	2(25%)	0.266	39(42.4%)
CSFWBC > 10 × 10 ⁶ /L (n) ^§	21/44(47.7%)	8/14(57.1%)	3/6(50%)	0.828	25/64(39.1%)
CSFPro ≥ 0.5 g/L (n) ^§	15/44(34.1%)	5/14(35.7%)	2/6(33.3%)	0.992	22/64(34.4%)
Ambulatory EEG abnormality (n) ^§	17/32(53.1%)	4/13(30.8%)	1/5(20%)	0.205	22/50(44%)
Head MRI abnormality (n) ^§	13/32(40.6%)	5/15(33.3%)	2/6(33.3%)	0.685	20/53(37.7%)
Patients with dysfunction upon discharge (n)	11(16.9%)	1(5.3%)	1(12.5%)	0.435	13(14.1%)
Death (n) ^¤	5(7.7%)	0	0	0.333	5(5.4%)

# There was no repeat counting in calculating the distribution of disease types. When neurogenic pulmonary edema or shock and brain stem encephalitis coexisted in the same patient, the former was counted. When neurogenic shock and pulmonary edema coexisted, pulmonary edema was counted. §The denominator of the fraction represents the cases examined, whereas the numerator represents the number of patients with this abnormality. ¤Among the 5 fatal cases, 2 died of neurogenic pulmonary edema, 2 died of shock and 1 patient was declared brain-dead

ISSN: 1743-422X