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Table 3 Data analysis of the clinical neurological damage caused by different pathogens

From: Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications

 

EV71

CA16

OE

p value

Total

Total (n)

65(70.7%)

19(20.7%)

8(8.7%)

 

92

Encephalitis (n) #

39(60%)

16(82.4%)

6(75%)

0.125

61(66.3%)

Acute flaccid paralysis (n) #

2(3%)

1(5.3%)

0

0.772

3(3.3%)

Brainstem encephalitis (n) #

8(12.3%)

2(1.1%)

0

0.572

10(10.9%)

Neurogenic pulmonary edema (n) #

11(16.9%)

0

1(12.5%)

0.047

11(12%)

Neurologic shock (n) #

5(7.7%)

0

1(12.5%)

0.215

6(6.5%)

Limb shaking (n)

51(78.5%)

15(78.9%)

6(75%)

0.973

72(78.3%)

Convulsion (n)

21(32.3%)

4(21.1%)

2(25%)

0.613

27(29.3%)

Vomiting (n)

42(64.6%)

16(84.2%)

7(87.5%)

0.141

65(70.7%)

Fatigue (n)

47(72.3%)

17(89.5%)

5(62.5%)

0.219

69(75%)

Coma (n)

24(36.9%)

2(10.5%)

1(12.5%)

0.046

27(29.3%)

Limb movement disorder (n)

34(52.3%)

3(15.8%)

2(25%)

0.010

39(42.4%)

Urinary retention (n)

31(47.7%)

6(31.6%)

2(25%)

0.266

39(42.4%)

CSFWBC > 10 × 10 6 /L (n) §

21/44(47.7%)

8/14(57.1%)

3/6(50%)

0.828

25/64(39.1%)

CSFPro ≥ 0.5 g/L (n) §

15/44(34.1%)

5/14(35.7%)

2/6(33.3%)

0.992

22/64(34.4%)

Ambulatory EEG abnormality (n) §

17/32(53.1%)

4/13(30.8%)

1/5(20%)

0.205

22/50(44%)

Head MRI abnormality (n) §

13/32(40.6%)

5/15(33.3%)

2/6(33.3%)

0.685

20/53(37.7%)

Patients with dysfunction upon discharge (n)

11(16.9%)

1(5.3%)

1(12.5%)

0.435

13(14.1%)

Death (n) ¤

5(7.7%)

0

0

0.333

5(5.4%)

  1. # There was no repeat counting in calculating the distribution of disease types. When neurogenic pulmonary edema or shock and brain stem encephalitis coexisted in the same patient, the former was counted. When neurogenic shock and pulmonary edema coexisted, pulmonary edema was counted. §The denominator of the fraction represents the cases examined, whereas the numerator represents the number of patients with this abnormality. ¤Among the 5 fatal cases, 2 died of neurogenic pulmonary edema, 2 died of shock and 1 patient was declared brain-dead