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Table 3 Data analysis of the clinical neurological damage caused by different pathogens

From: Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications

  EV71 CA16 OE p value Total
Total (n) 65(70.7%) 19(20.7%) 8(8.7%)   92
Encephalitis (n) # 39(60%) 16(82.4%) 6(75%) 0.125 61(66.3%)
Acute flaccid paralysis (n) # 2(3%) 1(5.3%) 0 0.772 3(3.3%)
Brainstem encephalitis (n) # 8(12.3%) 2(1.1%) 0 0.572 10(10.9%)
Neurogenic pulmonary edema (n) # 11(16.9%) 0 1(12.5%) 0.047 11(12%)
Neurologic shock (n) # 5(7.7%) 0 1(12.5%) 0.215 6(6.5%)
Limb shaking (n) 51(78.5%) 15(78.9%) 6(75%) 0.973 72(78.3%)
Convulsion (n) 21(32.3%) 4(21.1%) 2(25%) 0.613 27(29.3%)
Vomiting (n) 42(64.6%) 16(84.2%) 7(87.5%) 0.141 65(70.7%)
Fatigue (n) 47(72.3%) 17(89.5%) 5(62.5%) 0.219 69(75%)
Coma (n) 24(36.9%) 2(10.5%) 1(12.5%) 0.046 27(29.3%)
Limb movement disorder (n) 34(52.3%) 3(15.8%) 2(25%) 0.010 39(42.4%)
Urinary retention (n) 31(47.7%) 6(31.6%) 2(25%) 0.266 39(42.4%)
CSFWBC > 10 × 10 6 /L (n) § 21/44(47.7%) 8/14(57.1%) 3/6(50%) 0.828 25/64(39.1%)
CSFPro ≥ 0.5 g/L (n) § 15/44(34.1%) 5/14(35.7%) 2/6(33.3%) 0.992 22/64(34.4%)
Ambulatory EEG abnormality (n) § 17/32(53.1%) 4/13(30.8%) 1/5(20%) 0.205 22/50(44%)
Head MRI abnormality (n) § 13/32(40.6%) 5/15(33.3%) 2/6(33.3%) 0.685 20/53(37.7%)
Patients with dysfunction upon discharge (n) 11(16.9%) 1(5.3%) 1(12.5%) 0.435 13(14.1%)
Death (n) ¤ 5(7.7%) 0 0 0.333 5(5.4%)
  1. # There was no repeat counting in calculating the distribution of disease types. When neurogenic pulmonary edema or shock and brain stem encephalitis coexisted in the same patient, the former was counted. When neurogenic shock and pulmonary edema coexisted, pulmonary edema was counted. §The denominator of the fraction represents the cases examined, whereas the numerator represents the number of patients with this abnormality. ¤Among the 5 fatal cases, 2 died of neurogenic pulmonary edema, 2 died of shock and 1 patient was declared brain-dead