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Table 2 Comparison of the clinical data from patients with different enteroviruses

From: Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications

  EV71 CA16 OE p value Total
Total (n) 89 68 20   177
Gender (Male, n) 52(58.4%) 38(55.9%) 14(70%) 0.528 104(58.8%)
Age*(Years) 2.382 ± 2.102 2.588 ± 1.860 1.875 ± 1.146 0.347  
Region (from countryside, n) 57(64%) 41(60.3%) 13(65%) 0.868 111(62.3%)
Time from onset to hospitalization (d) 3.258 ± 1.176 4 ± 1.258 3.6 ± 1.353 0.001  
Duration of hospitalization (d) 14.337 ± 17.796 9.338 ± 3.366 8.1 ± 3.354 0.182  
WBC > 12 × 10 9 (n) 51(57.3%) 32(47.1%) 11(55%) 0.437 94(530.1%)
CRP > 8 mg/dl (n) 4(4.5%) 3(4.4%) 1(5%) 0.994 8(4.5%)
Duration of initial fever(d) 6.034 ± 3.131 5.706 ± 1.684 5.45 ± 1.468 0.547  
Highest fever temperature (°C) 39.144 ± 0.563 38.919 ± 0.494 38.92 ± 0.618 0.025  
Hand or foot rash (n) 81(91%) 67(98.5%) 20(100%) 0.057 168(94.9%)
Oral rash (n) 58(65.2%) 50(73.5%) 15(75%) 0.451 123(69.5%)
Buttock rash (n) 39(43.8%) 28(41.2%) 6(30%) 0.525 73(41.2%)
No rash (n) 3(2.2%) 0 0 0.221 3(1.7%)
Accompanied nervous system damage 65(73%) 19(27.9%) 8(40%) 0.000 92(52%)
Patients with dysfunction upon discharge (n) 11(12.4%) 1(1.5%) 1(5%) 0.030 13(7.3%)
Death (n) 5(7.3%) 0 0 0.030 5(2.8%)
  1. *Patients aged 0-12 months were counted as being 0.5 years of age; patients aged 1-2 years were counted as being 1.5 years of age; patients aged 2-3 years were counted as being 2.5 years of age, etc. ¤Among the 5 fatal cases, 2 patients died of neurogenic pulmonary edema, 2 died of shock, and 1 was diagnosed as being brain-dead. Statistically significant difference between groups A and B but no difference in comparison to the other 2 groups. There is statistically significant difference between group A and groups B and C but no difference in comparison to the other 2 groups