Table 1 Functional annotation of 38 differentially expressed genes
From: Screening and functional analysis of differentially expressed genes in EBV-transformed lymphoblasts
Notes | Generank | Fold Change | Edges | Gene Annotation |
|---|---|---|---|---|
Up-regulated genes | ||||
PLK1 | 12.04 | 5.44 | 49 | regulates M phase of cell cycle |
E2F1 | 10.51 | 3.01 | 18 | mediate cell proliferation and p53-dependent/indepent apoptosis |
AURKB | 10.07 | 5.13 | 39 | mitosis checkpoint |
CDK2 | 9.34 | 2.30 | 29 | cell cycle checkpoint |
PLCG2 | 8.93 | 2.18 | 10 | crucial enzyme in transmembrane signaling |
CD80 | 8.48 | 5.09 | 10 | costimulatory signal for T cell activation |
PIK3R3 | 7.39 | 2.94 | 15 | responsible for a range of cell functions |
CDC20 | 7.30 | 5.14 | 36 | regulates multiple points of cell cycle |
CDC6 | 6.90 | 5.75 | 26 | initiates of DNA repliaction |
AURKA | 6.88 | 5.27 | 21 | mitosis checkpoint |
CENPA | 6.87 | 6.87 | 28 | mitosis checkpoint |
BUB1B | 6.81 | 6.55 | 34 | mitosis checkpoint |
NUP37 | 6.37 | 3.08 | 29 | mitosis checkpoint |
MAD2L1 | 6.32 | 4.08 | 16 | spindle-assembly checkpoint |
BIRC5 | 6.04 | 5.53 | 36 | negative regulator of apoptosis |
CDC25A | 6.00 | 4.77 | 16 | cell cycle checkpoint |
CCNB1 | 5.81 | 5.81 | 18 | cell cycle checkpoint |
RPA3 | 5.64 | 2.42 | 17 | required for DNA recombination, repair and replication |
HJURP | 5.62 | 5.62 | 13 | fuctions in chromosome segregation |
KIF2C | 5.59 | 4.70 | 27 | fuctions in chromosome segregation |
CDK1 | 5.50 | 5.50 | 38 | cell cycle checkpoint |
CDCA8 | 5.45 | 5.27 | 26 | mitosis checkpoint |
Down-regulated genes | ||||
FYN | −19.27 | −4.92 | 34 | involved in B/T cell activation |
CD3D | −12.04 | −10.50 | 19 | involved in T/B-cell activation |
CD4 | −11.92 | −4.97 | 20 | MHC-II/T-cell receptor interacton |
CD3G | −11.91 | −9.81 | 19 | involved in T-cell activation |
ZAP70 | −11.69 | −6.20 | 21 | involved in T-cell development and activation |
FOS | −11.29 | −8.32 | 14 | involved in AP-1 and BCR/TCR signal pathway |
HCK | −10.11 | −5.28 | 17 | contributes to neutrophil migration and degranulation |
CD247 | −9.16 | −9.16 | 19 | regulates TCR expression and signal transduction |
PRKCQ | −9.10 | −7.15 | 10 | involved in T-cell activation |
ITK | −8.93 | −9.22 | 15 | involved in T-cell proliferation and differentiation |
LCP2 | −8.53 | −4.27 | 14 | involved in T-cell antigen receptor mediated signaling |
CXCL1 | −8.19 | −8.19 | 13 | has chemotactic activity for neutrophils |
CD8A | −8.08 | −9.86 | 15 | involved in T-cell mediated killing |
ITGB5 | −7.72 | −5.16 | 11 | receptor for fibronectin |
VAV3 | −7.60 | −4.55 | 10 | plays an important role in angiogenesis and FcϵRI signaling pathway |
CXCR4 | −7.20 | −4.22 | 10 | cytokine-cytokine receptor interaction |