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Figure 3 | Virology Journal

Figure 3

From: Evaluation of the immunogenicity of liposome encapsulated HVR1 and NS3 regions of genotype 3 HCV, either singly or in combination

Figure 3

a Serum anti-HVR1 and anti-NS3 IgG isotype titres at 2 weeks post-third dose in mice immunized with different antigen formulations at 0, 4 and 8 weeks. Values are represented as mean log 10 titre ± SE. *p-Value < 0.05 (t-test). a-1 to 3a-3: Serum antibody isotyping for individual HVR1 variants (variants 1, 3, and 4 respectively). a-4: Serum antibody isotyping for HVR1 variant pool. a-5: Serum antibody isotyping for HVR1 variant tetramer. a-6, 3a-7: Serum antibody isotyping for NS3. b: Cytokine profile in spleenocytes after in vitro stimulation with either HVR1 peptides or recombinant pNS3 at 2 weeks post-third dose in mice immunized with different antigen formulations at 0, 4 and 8 weeks. Values are represented as mean (pg/ml) ± SE. *p-Value ≤ 0.05 (Mann-Whitney test). b-1 to 3b-3: cytokine profile after stimulation with individual HVR1 variants1, 3, 4. b-4: cytokine profile after stimulation with HVR1 variant pool. b-5, 3b-6: cytokine profile after stimulation with recombinant pNS3.

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Virology Journal

ISSN: 1743-422X