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Table 1 Autophagy activity upon ATG knockdown

From: Inhibition of HIV-1 replication with stable RNAi-mediated knockdown of autophagy factors

Targeted ATG

Starvation-induced LC3 lipidation

Autophagy flux

WIPI1

+ a,b

+

Beclin1

+

+

PIK3R4

+

- c

Atg4A-1

+

+

Atg4A-3

+/- d

-

Atg5

+

-

Atg10-3

+

+

Atg10-5

+

+

Atg16

+

-

  1. a Results are representative of two separate experiments
  2. b +; LC3-II increase similar to that in control SupT1 cells
  3. c -; no LC3-II increase
  4. d +/-; minor LC3-II increase
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Virology Journal

ISSN: 1743-422X