Current status and future directions in the management of chronic hepatitis C

Table 4 A summary of current Hepatitis C drugs based on proteases, polymerase, and other degrading enzymes that are in preclinical development or in clinical trials

Drug Name	Pharma Co.	Class	Clinical Trial Phase
TMC435350	Tibotec & Medivir	Protease inhibitor	II
R1626	Roche	Nucleoside polymerase inhibitor	II
DEBIO-025	Debiopharm	Cyclophilin inhibitor	II
Celgosivir	Migenix	α-glucosidase inhibitor	II
BI12202	Boehringer	Protease inhibitor	I
MK-7009	Merck	Protease inhibitor	I
ITMN-191	InterMune & Roche	Protease inhibitor	I
NIM-811	Novartis	Cyclophilin inhibitor	I
R7128	Pharmasset & Roche	Nucleoside polymerase inhibitor	I
PSI-6130	Pharmasset	Nucleoside polymerase inhibitor	I
MK-0608	Merck	Nucleoside polymerase inhibitor	Preclinical

ISSN: 1743-422X