Table 4 Sequence similarities and characterization of differentially expressed transcripts of AF2240 NDV infected Chicken Brain
Clone | Accession | Homology | Putative | |
|---|---|---|---|---|
Name | Identity | Number | (%) | functional role |
DEG 1 | PREDICTED: Meleagris gallopavo n-sulphoglucosamine sulphohydrolase-like (LOC100549132), partial mRNA (down regulated) | XM_003211497 | 99% | Involved in proteoglycan metabolic process, as well as catalytic activity, hydrolase activity, metal ion binding and sulfuric ester hydrolase activity |
DEG 2 | Gallus gallus isolate YP20092 breed Chigulu mitochondrion, complete genome (up regulated) | GU261719 | 96% | Â |
DEG 3 | Gallus gallus interleukin 8 (IL8), mRNA (up regulated) | NM_205498 | 98% | Chemokine produced by macrophages and other cell types such as epithelial cells. It is one of the major mediators of the inflammatory response, particularly, serves as a chemical signal that attracts neutrophils at the site of inflammation. |
DEG 4 | Gallus gallus heat shock 60 kDa protein 1 (chaperonin) (HSPD1), nuclear gene encoding mitochondrial protein, mRNA (up regulated) | NM_001012916 | 99% | Protein folding, stress response. |
DEG 5 | G.gallus gene for beta-2 microglobulin (clone RG6) (up regulated) | Z48931 | 90% | Component of MHC class I molecules, which are present on all nucleated cells. |
DEG 6 | Gallus gallus finished cDNA, clone ChEST292n17 (down regulated) | CR391527 | 88% | Â |
DEG 7 | Sus scrofa calcium transporter 1 (TRPV6) mRNA, partial cds (up regulated) | FJ268731 | 90% | Member of the Transient receptor potential (TRP) family of membrane proteins, involved in Ca2+reabsorption. |
DEG 8 | Gallus gallus contactin associated protein-like 5 (CNTNAP5), mRNA (up regulated) | NM_001048079 | 96% | Member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors play a role in the local differentiation of the axon into distinct functional subdomains. |
DEG 9 | Gallus gallus finished cDNA, clone ChEST317g8 (down regulated) | CR389719 | 90% | Â |
DEG 10 | Unknown sequence (down regulated) | Â | Â | Â |
DEG 11 | PREDICTED: Gallus gallus similar to CD163 molecule (LOC776417), mRNA (down regulated) | XM_001235940 | 99% | Member of the scavenger receptor family with cysteine-rich domains (SCRC) identified as a receptor of haptoglobin-hemoglobin (Hp-Hb) and exclusively expressed in cells of monocyte-macrophage lineage |