(A) CryoEM image of HPV 16 VLPs post-D/R treatment shows a field of well-formed closed spherical particles. (B,C) Larger scale images of individual VLP particles show that the individual capsomeres are arranged with a high degree of order. (D) CryoTEM image of post D/R HPV 16 VLPs mixed with H16.V5 Fab shows a similar field of particles densely decorated with antibody fragment. (E, F) Larger scale images of individual particles show that the antibody attachment is independent of the diameter of the individual particles. Scale bar is 200 nm.