Table 2 Distribution of aa mutations in EBNA-2 functional domains
Functional domains | Residues | EBVaGC(n = 25) | NPC(n = 56) | TWs(n = 32) |
|---|---|---|---|---|
Self-association | 163(R-M) | 25(100%) | 56(100%) | 32(100%) |
NLS | 291(P-T) | 1(4%) | 14(25%) | 3(9.4%) |
| Â | 294(Qdel) | 2(8%) | 14(25%) | 3(9.4%) |
RG domain | 357(Kdel) | 5(20%) | 31(55.4%) | 13(40.6%) |
| Â | 358(Gdel) | 5(20%) | 31(55.4%) | 13(40.6%) |
TAD | 438(I-L) | 0 | 3(5.4%) | 0 |
NLS | 476(E-G) | 0 | 14(25%) | 0 |
| Â | 484(P-H) | 0 | 4(7.1%) | 0 |
| Â | 486(I-T) | 0 | 14(25%) | 0 |