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Table 2 Assessment by odds ratio analysis for an outcome if a risk factor is present

From: Paradoxical expression of IL-28B mRNA in peripheral blood in human T-cell leukemia virus Type-1 mono-infection and co-infection with hepatitis C Virus

  factor
(A) Outcome dependent independent Odds ratio 95%CI P
1) HTLV-1 mono-infection TT vs TG/GG 1.11 0.62-1.99 0.72
2) Co-infection TT vs TG/GG 0.54 0.04-6.88 1.00
3) High mRNA Expression* TT vs TG/GG 6.25 1.16-33.75 0.04
4) ATL (B) TT vs TG/GG 1.50 0.60-3.75 0.39
5) Low mRNA Expression HTLV-1 mono vs DN 0.34 0.06-2.04 0.24
6) Low mRNA Expression HCV mono vs DN 0.29 0.07-2.23 0.15
7)) Low mRNA Expression Co-Inf** vs HTLV-1-mono** 9.5 2.06-43.76 0.004
8) ATL low expression or not 0.8 0.14-4.74 0.81
  1. (A) Upper 4 lines; assessing the risk of 1) HTLV-1 persistent infection, 2) super-imposed HTLV-1 infection with HCV (co-infection), 3) high IL-28B mRNA expression, and 4) ATL development when the genotype is a risk factor (B) Lower 4 lines; assessing the risk factors described in the outcome, the IL-28B mRNA expression level in peripheral blood (5, 6, and 7), and ATL development (8). Consequently, similarly to HCV, HTLV-1 is associated with up-regulation of IL-28B mRNA along with the TT homozygote, and co-infection with HTLV-1 and HCV paradoxically down-regulates the mRNA level
  2. *; IL-28B Expression level, Co-inf = co-infection with HTLV-1 and HCV, mono = mono-infection
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