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Table 2 Assessment by odds ratio analysis for an outcome if a risk factor is present

From: Paradoxical expression of IL-28B mRNA in peripheral blood in human T-cell leukemia virus Type-1 mono-infection and co-infection with hepatitis C Virus

 

factor

(A) Outcome

dependent independent

Odds ratio

95%CI

P

1) HTLV-1 mono-infection

TT vs TG/GG

1.11

0.62-1.99

0.72

2) Co-infection

TT vs TG/GG

0.54

0.04-6.88

1.00

3) High mRNA Expression*

TT vs TG/GG

6.25

1.16-33.75

0.04

4) ATL

(B)

TT vs TG/GG

1.50

0.60-3.75

0.39

5) Low mRNA Expression

HTLV-1 mono vs DN

0.34

0.06-2.04

0.24

6) Low mRNA Expression

HCV mono vs DN

0.29

0.07-2.23

0.15

7)) Low mRNA Expression

Co-Inf** vs HTLV-1-mono**

9.5

2.06-43.76

0.004

8) ATL

low expression or not

0.8

0.14-4.74

0.81

  1. (A) Upper 4 lines; assessing the risk of 1) HTLV-1 persistent infection, 2) super-imposed HTLV-1 infection with HCV (co-infection), 3) high IL-28B mRNA expression, and 4) ATL development when the genotype is a risk factor (B) Lower 4 lines; assessing the risk factors described in the outcome, the IL-28B mRNA expression level in peripheral blood (5, 6, and 7), and ATL development (8). Consequently, similarly to HCV, HTLV-1 is associated with up-regulation of IL-28B mRNA along with the TT homozygote, and co-infection with HTLV-1 and HCV paradoxically down-regulates the mRNA level
  2. *; IL-28B Expression level, Co-inf = co-infection with HTLV-1 and HCV, mono = mono-infection
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Virology Journal

ISSN: 1743-422X