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Figure 5 | Virology Journal

Figure 5

From: Design of different strategies of multivalent DNA-based vaccination against rabies and canine distemper in mice and dogs

Figure 5

Rabies-virus-neutralizing antibody titers in mice inoculated with different monovalent or multivalent DNA-based vaccine candidates or cell-culture-derived vaccines. Groups of mice were administered intramuscularly either pCMV3ISS-GPV; or pCMV3ISS-GPV-CDVH; or pCMV3ISS-GPV-2A-CDVH; or pCMV3ISS-GPV-IRES-CDVH, 50 μg each, or pCMV3ISS-GPV and pCMV3ISS-CDVH (50 μg, each); or pCMV3ISS-GPV-CDVH (100 μg); or 200 μl of Rabisin® and compared to sham vaccinated group (50 μg of pCMV3ISS) and non-vaccinated group (PBS). All the mice were blood-sampled at Days 14, 28 and 365 post-vaccination. Results correspond to mean antibody titers of 5 mice per group expressed in IU/ml of serum as measured by RFFIT. Stars indicate statistical significances of differences between groups of mice administered the multivalent plasmid compared to those administered the monovalent plasmid pCMV3ISS-GPV.

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Virology Journal

ISSN: 1743-422X