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Table 1 Resistance profile against wild type and RT mutant VSV-G pseudotyped HIV-1 vectors

From: Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase

Inhibitor

Antiviral EC50 (μM)a, b

CC50 (μM)c

 

wt

Y188L

Y181C

V106A

K103N

 

F2

0.165 ± 0.039

> 20

1.676 ± 0.271

1.275 ± 0.357

3.233 ± 0.127

34.1 ± 2.4

  

[>121.1]

[10.2]

[7.7]

[19.6]

 

NVP

0.019 ± 0.002

> 20

2.879 ± 0.006

1.260 ± 0.159

0.841 ± 0.049

> 50

  

[>1052.6]

[151.5]

[66.3]

[44.2]

 

AZT

0.014 ± 0.003

0.011 ± 0.005

0.006 ± 0.0

0.015 ± 0.001

0.014 ± 0.002

> 50

  

[0.8]

[0.4]

[1.1]

[1.0]

 
  1. a Values are averages ± standard deviations from two independent experiments performed in duplicate in 293T cells.
  2. b The viruses were produced by cotransfection of the pNLNgoMIV R+E-.luc wild type or RT mutant plasmids and VSVg expressing plasmid. The values in brackets indicate the fold change in EC50 for mutant relative to wild type.
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Virology Journal

ISSN: 1743-422X