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Table 1 Resistance profile against wild type and RT mutant VSV-G pseudotyped HIV-1 vectors

From: Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase

Inhibitor Antiviral EC50 (μM)a, b CC50 (μM)c
  wt Y188L Y181C V106A K103N  
F2 0.165 ± 0.039 > 20 1.676 ± 0.271 1.275 ± 0.357 3.233 ± 0.127 34.1 ± 2.4
   [>121.1] [10.2] [7.7] [19.6]  
NVP 0.019 ± 0.002 > 20 2.879 ± 0.006 1.260 ± 0.159 0.841 ± 0.049 > 50
   [>1052.6] [151.5] [66.3] [44.2]  
AZT 0.014 ± 0.003 0.011 ± 0.005 0.006 ± 0.0 0.015 ± 0.001 0.014 ± 0.002 > 50
   [0.8] [0.4] [1.1] [1.0]  
  1. a Values are averages ± standard deviations from two independent experiments performed in duplicate in 293T cells.
  2. b The viruses were produced by cotransfection of the pNLNgoMIV R+E-.luc wild type or RT mutant plasmids and VSVg expressing plasmid. The values in brackets indicate the fold change in EC50 for mutant relative to wild type.