Group | Immunization | Ab responses (ELISA, 2n)a | Serum IgG subclasses (ELISA, 2n)a | IgG2a/ IgG1 Ratio | ||||
---|---|---|---|---|---|---|---|---|
DNA prime | rNP boost | Serum IgG | Nasal wash IgA | Lung wash IgA | IgG2a | IgG1 | ||
D1 | once | - | 11.40±2.17 | - | - | 11.83±2.71 | 10.25±0.96 | 2.99 |
D2 | twice | - | 17.00±0.70 | - | - | 18.44±1.23 | 16.10±0.79 | 5.06 |
P1 | - | once | 18.20±0.45 | 0.89±0.19 | 6.50±0.53 | 15.50±1.37 | 17.89±1.01 | 0.19 |
D1P1 | once | once | 21.60±0.89b, c | 2.67±0.46c | 8.67±0.87c | 21.55±1.50 | 19.25±0.82 | 4.92 |
D2P1 | twice | once | 24.80±0.83c, d, e | 4.56±0.38c, e | 11.30±1.12c, e | 24.11±1.00 | 20.80±0.92 | 9.92 |
Control | - | - | - | - | - | - | - | - |