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Figure 6 | Virology Journal

Figure 6

From: Human immunodeficiency virus type 1 Vpu and cellular TASK proteins suppress transcription of unintegrated HIV-1 DNA

Figure 6

TASK-1 and Vpu preferentially suppress transcription of cells infected with Integrase defective HIV-1. Jurkat cells were transfected with empty vector (EV), TASK-1 or Vpu expression plasmids and then infected with wildtype NL4-3-CFP (A) or NL4-3D116N-YFP (B). Twenty four hours after infection the cells were lysed and total RNA was isolated and used as template for real-time PCR to measure nef mRNA. Data shown are normalized to EV control. (* P = .0002; **P < .0001; Student T test was used to determine statistical significance).

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Virology Journal

ISSN: 1743-422X